Trait
Low blood calcium levels
Clinical name: Hypocalcemia
The concentration of calcium in the blood circulation is below the lower limit of normal.
Summary
- Also called
- Decreased calcium(2+) concentration, Decreased calcium(2+) level, Decreased calcium(2+) level in blood, Hypocalcaemia, Reduced calcium(2+) concentration, Reduced calcium(2+) level, Reduced calcium(2+) level in blood
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Get my Genome Test83 genes linked to Low blood calcium levels
Changes in these genes cause rare conditions in which Low blood calcium levels is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALG12ALG12 alpha-1,6-mannosyltransferase | Always | In 1 condition |
| ATP6V1B1ATPase H+ transporting V1 subunit B1 | Always | In 1 condition |
| CASRcalcium sensing receptor | Always | In 2 conditions |
| CYP27B1cytochrome P450 family 27 subfamily B member 1 | Always | In 2 conditions |
| CYP2R1cytochrome P450 family 2 subfamily R member 1 | Always | In 2 conditions |
| FAM111AFAM111 trypsin like peptidase A | Always | In 2 conditions |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Always | In 1 condition |
| GCM2GCM transcription factor 2 | Always | In 2 conditions |
| GNA11G protein subunit alpha 11 | Always | In 2 conditions |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Always | In 1 condition |
| PTHparathyroid hormone | Always | In 1 condition |
| TBCEtubulin folding cofactor E | Always | In 4 conditions |
| TRPM6transient receptor potential cation channel subfamily M member 6 | Always | In 1 condition |
| GNASGNAS complex locus | Very often (80–99%) | In 6 conditions |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Very often (80–99%) | In 1 condition |
| RRAGDRas related GTP binding D | Very often (80–99%) | In 2 conditions |
| STX16syntaxin 16 | Very often (80–99%) | In 2 conditions |
| VDRvitamin D receptor | Very often (80–99%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Often (30–79%) | In 1 condition |
| BTKBruton tyrosine kinase | Often (30–79%) | In 1 condition |
| CA2carbonic anhydrase 2 | Often (30–79%) | In 1 condition |
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Often (30–79%) | In 1 condition |
| CAMKMTcalmodulin-lysine N-methyltransferase | Often (30–79%) | In 1 condition |
| CLDN16claudin 16 | Often (30–79%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Often (30–79%) | In 1 condition |
| GATA3GATA binding protein 3 | Often (30–79%) | In 1 condition |
| GEMIN4gem nuclear organelle associated protein 4 | Often (30–79%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Often (30–79%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Often (30–79%) | In 1 condition |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Often (30–79%) | In 1 condition |
| HIRAhistone cell cycle regulator | Often (30–79%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Often (30–79%) | In 1 condition |
| PPM1Bprotein phosphatase, Mg2+/Mn2+ dependent 1B | Often (30–79%) | In 1 condition |
| PREPLprolyl endopeptidase like | Often (30–79%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Often (30–79%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Often (30–79%) | In 1 condition |
| SLC3A1solute carrier family 3 member 1 | Often (30–79%) | In 1 condition |
| TBX1T-box transcription factor 1 | Often (30–79%) | In 3 conditions |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Often (30–79%) | In 3 conditions |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Often (30–79%) | In 1 condition |
Show 43 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| USP53ubiquitin specific peptidase 53 | Often (30–79%) | In 1 condition |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Sometimes (5–29%) | In 1 condition |
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Sometimes (5–29%) | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Sometimes (5–29%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Sometimes (5–29%) | In 3 conditions |
| CLCNKBchloride voltage-gated channel Kb | Sometimes (5–29%) | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Sometimes (5–29%) | In 1 condition |
| DGCR2DiGeorge syndrome critical region gene 2 | Sometimes (5–29%) | In 1 condition |
| DGCR6DiGeorge syndrome critical region gene 6 | Sometimes (5–29%) | In 1 condition |
| DGCR8DGCR8 microprocessor complex subunit | Sometimes (5–29%) | In 1 condition |
| ESS2ess-2 spliceosome associated protein | Sometimes (5–29%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| FOCADfocadhesin | Sometimes (5–29%) | In 1 condition |
| FOXP3forkhead box P3 | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Sometimes (5–29%) | In 1 condition |
| IVDisovaleryl-CoA dehydrogenase | Sometimes (5–29%) | In 1 condition |
| LPIN1lipin 1 | Sometimes (5–29%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Sometimes (5–29%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Sometimes (5–29%) | In 1 condition |
| OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | Sometimes (5–29%) | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Sometimes (5–29%) | In 2 conditions |
| PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha | Sometimes (5–29%) | In 2 conditions |
| RFX7regulatory factor X7 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Sometimes (5–29%) | In 1 condition |
| SNX10sorting nexin 10 | Sometimes (5–29%) | In 1 condition |
| TNFSF11TNF superfamily member 11 | Sometimes (5–29%) | In 1 condition |
| ACADVLacyl-CoA dehydrogenase very long chain | Rarely (1–4%) | In 1 condition |
| CSF1Rcolony stimulating factor 1 receptor | Rarely (1–4%) | In 1 condition |
| FGF23fibroblast growth factor 23 | Rarely (1–4%) | In 1 condition |
| CAV1caveolin 1 | Not recorded | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Not recorded | In 1 condition |
| CYP3A4cytochrome P450 family 3 subfamily A member 4 | Not recorded | In 1 condition |
| GNAS-AS1GNAS antisense RNA 1 | Not recorded | In 1 condition |
| HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 | Not recorded | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Not recorded | In 1 condition |
| IFT122intraflagellar transport 122 | Not recorded | In 1 condition |
| PLEKHM1pleckstrin homology and RUN domain containing M1 | Not recorded | In 1 condition |
| PLVAPplasmalemma vesicle associated protein | Not recorded | In 1 condition |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Not recorded | In 1 condition |
| UBR1ubiquitin protein ligase E3 component n-recognin 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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