Trait
Reduced circulating complement concentration
An immunodeficiency defined by the absent or suboptimal functioning of one of the complement system proteins.
Summary
- Also called
- Complement deficiency
- Body system
- Abnormality of the immune system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test5 genes linked to Reduced circulating complement concentration
Changes in these genes cause rare conditions in which Reduced circulating complement concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| MASP2MBL associated serine protease 2 | Always | In 1 condition |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| DNASE1L3deoxyribonuclease 1L3 | Very often (80–99%) | In 1 condition |
| GALK1galactokinase 1 | Rarely (1–4%) | In 1 condition |
| SLC7A7solute carrier family 7 member 7 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Decreased circulating complement C3 concentration45 genes
- Decreased circulating complement C4 concentration35 genes
- Decreased circulating complement factor B concentration5 genes
- Decreased circulating complement factor I concentration5 genes
- Decreased circulating complement factor H concentration4 genes
- Decreased circulating C1q concentration2 genes
- Partial functional complement factor D deficiency1 gene
- Decreased circulating terminal complement component concentration
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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