Trait
Generalized scaling
Desquamation (scaling) involving nearly all of the surface of the skin.
Summary
- Also called
- Diffuse desquamation, Diffuse scaling
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test11 genes linked to Generalized scaling
Changes in these genes cause rare conditions in which Generalized scaling is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| SPINK5serine peptidase inhibitor Kazal type 5 | Always | In 2 conditions |
| ABCA12ATP binding cassette subfamily A member 12 | Very often (80–99%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Very often (80–99%) | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Very often (80–99%) | In 1 condition |
| ASPRV1aspartic peptidase retroviral like 1 | Very often (80–99%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Very often (80–99%) | In 1 condition |
| LIPNlipase family member N | Very often (80–99%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Very often (80–99%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Very often (80–99%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Very often (80–99%) | In 1 condition |
| TGM1transglutaminase 1 | Very often (80–99%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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