Trait
Stiff skin
An induration (hardening) of the skin
Summary
- Also called
- Indurated skin, Skin induration
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test18 genes linked to Stiff skin
Changes in these genes cause rare conditions in which Stiff skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DONSONDNA replication fork stabilization factor DONSON | Always | In 1 condition |
| FBN1fibrillin 1 | Always | In 1 condition |
| LMNAlamin A/C | Always | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Always | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Very often (80–99%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Very often (80–99%) | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Very often (80–99%) | In 1 condition |
| ASPRV1aspartic peptidase retroviral like 1 | Very often (80–99%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Very often (80–99%) | In 1 condition |
| LIPNlipase family member N | Very often (80–99%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Very often (80–99%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Very often (80–99%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Very often (80–99%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Very often (80–99%) | In 1 condition |
| TGM1transglutaminase 1 | Very often (80–99%) | In 1 condition |
| ADA2adenosine deaminase 2 | Often (30–79%) | In 1 condition |
| SMAD4SMAD family member 4 | Often (30–79%) | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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