Trait
Eyelids stay open
Clinical name: Lagophthalmos
A condition in which the eyelids do not close to cover the eye completely.
Summary
- Also called
- Inability to close the eyelids
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
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Get my Genome Test23 genes linked to Eyelids stay open
Changes in these genes cause rare conditions in which Eyelids stay open is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CDH1cadherin 1 | Always | In 1 condition |
| DLX4distal-less homeobox 4 | Always | In 1 condition |
| HOXB1homeobox B1 | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| MYMKmyomaker, myoblast fusion factor | Always | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Often (30–79%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Often (30–79%) | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Often (30–79%) | In 1 condition |
| ASPRV1aspartic peptidase retroviral like 1 | Often (30–79%) | In 1 condition |
| CTNND1catenin delta 1 | Often (30–79%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Often (30–79%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Often (30–79%) | In 1 condition |
| LIPNlipase family member N | Often (30–79%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Often (30–79%) | In 1 condition |
| PRR12proline rich 12 | Often (30–79%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Often (30–79%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Often (30–79%) | In 1 condition |
| TGM1transglutaminase 1 | Often (30–79%) | In 1 condition |
| ECEL1endothelin converting enzyme like 1 | Sometimes (5–29%) | In 1 condition |
| KDM6Alysine demethylase 6A | Sometimes (5–29%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Sometimes (5–29%) | In 1 condition |
| NGLY1N-glycanase 1 | Rarely (1–4%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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