Trait
Euryblepharon
Euryblepharon is a congenital eyelid anomaly characterized by horizontal enlargement of the palpebral fissure. The eyelid is shortened vertically compared with the horizontal dimension, with associated lateral canthal malpositioning and lateral ectropion abnormally wide lid opening.
Summary
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test19 genes linked to Euryblepharon
Changes in these genes cause rare conditions in which Euryblepharon is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CDH1cadherin 1 | Always | In 2 conditions |
| DLX4distal-less homeobox 4 | Always | In 1 condition |
| ACTBactin beta | Very often (80–99%) | In 1 condition |
| ACTG1actin gamma 1 | Very often (80–99%) | In 1 condition |
| CTNND1catenin delta 1 | Often (30–79%) | In 2 conditions |
| DVL1dishevelled segment polarity protein 1 | Often (30–79%) | In 1 condition |
| DVL3dishevelled segment polarity protein 3 | Often (30–79%) | In 1 condition |
| FZD2frizzled class receptor 2 | Often (30–79%) | In 1 condition |
| WNT5AWnt family member 5A | Often (30–79%) | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Sometimes (5–29%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Sometimes (5–29%) | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Sometimes (5–29%) | In 1 condition |
| ASPRV1aspartic peptidase retroviral like 1 | Sometimes (5–29%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Sometimes (5–29%) | In 1 condition |
| LIPNlipase family member N | Sometimes (5–29%) | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Sometimes (5–29%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Sometimes (5–29%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Sometimes (5–29%) | In 1 condition |
| TGM1transglutaminase 1 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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