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Gene

PFAS

phosphoribosylformylglycinamidine synthase

Summary

Cytogenetic location
17p13.1
Coordinates
Chromosome 17: 8,249,289–8,270,486 (GRCh38)
Exons
28 exons across 21.2 kb
Protein
1,338 amino acids
Also known as
PURL, FGARAT, KIAA0361, GATD8
MANE Select transcript
ENST00000314666.11NM_012393.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PFAS yet. The test sequences your whole genome, so your data includes it all the same.

How PFAS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 17, with a bracket where PFAS sits. PFAS and 35 genes near it on chromosome 17, from 7,759,888 to 8,759,887.Chromosome 1717p13.1p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.37.8 Mb8 Mb8.2 Mb8.4 Mb8.6 MbDNAH2: 7,717,728–7,833,742, forward strandDNAH2KDM6B: 7,834,193–7,854,808, forward strandKDM6BTMEM88: 7,855,057–7,856,114, forward strandTMEM88NAA38: 7,856,681–7,885,238, reverse strandNAA38CYB5D1: 7,857,696–7,862,282, forward strandCYB5D1CHD3: 7,884,787–7,912,760, forward strandRNF227: 7,913,238–7,916,377, reverse strandKCNAB3: 7,920,956–7,929,856, reverse strandKCNAB3: 7,925,931–7,930,622, reverse strandTRAPPC1: 7,930,345–7,932,123, reverse strandTRAPPC1CNTROB: 7,932,101–7,949,953, forward strandCNTROBGUCY2D: 8,002,615–8,020,342, forward strandGUCY2DALOX15B: 8,039,011–8,049,134, forward strandALOX15BALOX12B: 8,068,594–8,087,716, reverse strandALOX12BALOXE3: 8,095,900–8,119,047, reverse strandALOXE3HES7: 8,120,592–8,124,114, reverse strandHES7PER1: 8,140,467–8,156,506, reverse strand: 8,150,816–8,162,975, reverse strandVAMP2: 8,159,149–8,163,584, reverse strandVAMP2TMEM107: 8,172,440–8,176,408, reverse strandTMEM107BORCS6: 8,188,345–8,190,180, reverse strandBORCS6AURKB: 8,204,335–8,210,638, reverse strandAURKBCTC1: 8,224,815–8,248,075, reverse strandCTC1PFAS: 8,249,289–8,270,486, forward strandPFASSLC25A35: 8,287,762–8,295,410, reverse strandSLC25A35RANGRF: 8,288,631–8,290,092, forward strandRANGRFARHGEF15: 8,310,222–8,323,203, forward strandARHGEF15ODF4: 8,339,840–8,346,048, forward strandODF4KRABD2: 8,356,902–8,376,738, reverse strandKRABD2: 8,368,638–8,383,187, reverse strandRPL26: 8,377,500–8,384,062, reverse strandRNF222: 8,390,702–8,397,827, reverse strandRNF222NDEL1: 8,408,528–8,501,107, forward strandNDEL1MYH10: 8,474,205–8,632,303, reverse strandMYH10CCDC42: 8,729,930–8,745,970, reverse strandCCDC42SPDYE4: 8,747,524–8,758,559, reverse strandSPDYE4Diagram of PFAS: 28 exons on the forward strand of chromosome 17Exon 1: 8,249,289–8,249,339, 51 basesExon 2: 8,253,859–8,254,079, 221 basesExon 3: 8,254,166–8,254,301, 136 basesExon 4: 8,255,027–8,255,132, 106 basesExon 5: 8,255,502–8,255,691, 190 basesExon 6: 8,255,805–8,255,910, 106 basesExon 7: 8,256,267–8,256,407, 141 basesExon 8: 8,256,524–8,256,648, 125 basesExon 9: 8,256,835–8,256,963, 129 basesExon 10: 8,257,807–8,257,938, 132 basesExon 11: 8,258,071–8,258,199, 129 basesExon 12: 8,262,920–8,262,993, 74 basesExon 13: 8,263,109–8,263,265, 157 basesExon 14: 8,263,575–8,263,636, 62 basesExon 15: 8,263,775–8,263,936, 162 basesExon 16: 8,264,212–8,264,337, 126 basesExon 17: 8,264,470–8,264,601, 132 basesExon 18: 8,264,895–8,265,125, 231 basesExon 19: 8,265,288–8,265,468, 181 basesExon 20: 8,265,556–8,265,639, 84 basesExon 21: 8,265,862–8,266,017, 156 basesExon 22: 8,266,234–8,266,353, 120 basesExon 23: 8,266,753–8,266,898, 146 basesExon 24: 8,267,028–8,267,235, 208 basesExon 25: 8,267,372–8,267,463, 92 basesExon 26: 8,267,551–8,267,665, 115 basesExon 27: 8,268,533–8,268,856, 324 basesExon 28: 8,268,954–8,270,486, 1,533 bases1510152025285′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.4 kb of the gene's 21.2 kb; 4,017 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). PFAS gene: phosphoribosylformylglycinamidine synthase. Retrieved 17 October 2026, from https://dantelabs.com/genes/pfas

Vancouver

Dante Labs. PFAS gene: phosphoribosylformylglycinamidine synthase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pfas

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