Trait
Hypergranulosis
Hypergranulosis is an increased thickness of the stratum granulosum.
Summary
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test24 genes linked to Hypergranulosis
Changes in these genes cause rare conditions in which Hypergranulosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DSG1desmoglein 1 | Always | In 2 conditions |
| GJA1gap junction protein alpha 1 | Always | In 1 condition |
| KRT10keratin 10 | Always | In 1 condition |
| LIPNlipase family member N | Always | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Always | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Always | In 2 conditions |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Very often (80–99%) | In 1 condition |
| AAGABalpha and gamma adaptin binding protein | Often (30–79%) | In 2 conditions |
| CCDC91coiled-coil domain containing 91 | Often (30–79%) | In 1 condition |
| COL14A1collagen type XIV alpha 1 chain | Often (30–79%) | In 1 condition |
| LORICRINloricrin cornified envelope precursor protein | Often (30–79%) | In 2 conditions |
| KRT1keratin 1 | Sometimes (5–29%) | In 1 condition |
| KRT16keratin 16 | Sometimes (5–29%) | In 1 condition |
| KRT9keratin 9 | Sometimes (5–29%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Not recorded | In 1 condition |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Not recorded | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Not recorded | In 1 condition |
| CERS3ceramide synthase 3 | Not recorded | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Not recorded | In 1 condition |
| GJB3gap junction protein beta 3 | Not recorded | In 1 condition |
| PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase | Not recorded | In 1 condition |
| POGLUT1protein O-glucosyltransferase 1 | Not recorded | In 1 condition |
| SERPINB7serpin family B member 7 | Not recorded | In 1 condition |
| WNT10AWnt family member 10A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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