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Gene

SLC4A2

solute carrier family 4 member 2

Summary

Cytogenetic location
7q36.1
Coordinates
Chromosome 7: 151,059,589–151,076,523 (GRCh38)
Exons
23 exons across 16.9 kb
Protein
1,241 amino acids
Also known as
HKB3, BND3L, NBND3
Previous symbols
EPB3L1, AE2
MANE Select transcript
ENST00000413384.7NM_003040.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Spherocytosis

    • Hereditary spherocytosis is a congenital hemolytic anemia with a wide clinical spectrum (from symptom-free carriers to severe hemolysis) characterized by anemia, variable jaundice, splenomegaly and cholelithiasis.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Folic acid supplementation; splenectomy for moderate-severe disease (partial or total); pre-splenectomy vaccination; cholecystectomy for gallstones; transfusion support during aplastic crises; monitoring for parvovirus B19

How SLC4A2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 7, with a bracket where SLC4A2 sits. SLC4A2 and 32 genes near it on chromosome 7, from 150,568,056 to 151,568,055.Chromosome 77q36.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3150.6 Mb150.8 Mb151 Mb151.2 Mb151.4 MbGIMAP4: 150,567,242–150,574,512, forward strandGIMAP4GIMAP6: 150,625,375–150,632,651, reverse strandGIMAP6GIMAP2: 150,685,647–150,694,763, forward strandGIMAP2GIMAP1: 150,716,606–150,724,284, forward strandGIMAP1GIMAP1-GIMAP5: 150,716,668–150,743,646, forward strandGIMAP1-GIMAP5GIMAP5: 150,722,253–150,750,033, forward strandGIMAP5TMEM176B: 150,789,455–150,823,877, reverse strandTMEM176BTMEM176A: 150,799,598–150,805,122, forward strandTMEM176AAOC1: 150,824,627–150,872,465, forward strandAOC1KCNH2: 150,944,064–150,978,394, reverse strandKCNH2NOS3: 150,991,017–151,015,653, forward strandNOS3ATG9B: 151,012,209–151,024,499, reverse strandATG9BABCB8: 151,028,422–151,047,782, forward strandASIC3: 151,048,292–151,052,756, forward strandCDK5: 151,051,517–151,057,952, reverse strandCDK5SLC4A2: 151,059,589–151,076,523, forward strandSLC4A2: 151,061,928–151,061,978, forward strandFASTK: 151,076,585–151,080,881, reverse strandFASTKTMUB1: 151,081,082–151,083,533, reverse strandAGAP3: 151,085,831–151,144,450, forward strandAGAP3GBX1: 151,147,669–151,174,745, reverse strandGBX1ASB10: 151,175,684–151,187,832, reverse strandASB10DRC11L: 151,190,873–151,205,496, reverse strandDRC11LH2BK1: 151,207,416–151,210,488, reverse strandH2BK1ABCF2-H2BK1: 151,207,837–151,227,166, reverse strandABCF2: 151,211,484–151,227,264, reverse strandCHPF2: 151,232,483–151,240,979, forward strandSMARCD3: 151,238,764–151,277,896, reverse strandNUB1: 151,341,704–151,381,097, forward strandNUB1WDR86: 151,375,909–151,410,727, reverse strandWDR86CRYGN: 151,428,293–151,440,813, reverse strandCRYGNRHEB: 151,465,976–151,520,120, reverse strandRHEBPRKAG2: 151,556,010–151,877,563, reverse strandPRKAG2Diagram of SLC4A2: 23 exons on the forward strand of chromosome 7Exon 1: 151,059,589–151,059,762, 174 basesExon 2: 151,061,925–151,062,038, 114 basesExon 3: 151,064,202–151,064,367, 166 basesExon 4: 151,064,526–151,064,767, 242 basesExon 5: 151,064,848–151,064,966, 119 basesExon 6: 151,066,517–151,066,761, 245 basesExon 7: 151,066,851–151,066,993, 143 basesExon 8: 151,067,874–151,068,054, 181 basesExon 9: 151,069,947–151,070,082, 136 basesExon 10: 151,070,181–151,070,346, 166 basesExon 11: 151,070,457–151,070,571, 115 basesExon 12: 151,070,727–151,070,911, 185 basesExon 13: 151,071,072–151,071,297, 226 basesExon 14: 151,071,390–151,071,605, 216 basesExon 15: 151,071,689–151,071,837, 149 basesExon 16: 151,071,942–151,072,136, 195 basesExon 17: 151,074,039–151,074,293, 255 basesExon 18: 151,074,399–151,074,488, 90 basesExon 19: 151,074,675–151,074,841, 167 basesExon 20: 151,075,255–151,075,508, 254 basesExon 21: 151,075,606–151,075,775, 170 basesExon 22: 151,076,013–151,076,186, 174 basesExon 23: 151,076,287–151,076,523, 237 bases15101520235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 16.9 kb; 3,726 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC4A2 gene: solute carrier family 4 member 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc4a2

Vancouver

Dante Labs. SLC4A2 gene: solute carrier family 4 member 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc4a2

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