Gene
KLF11
KLF transcription factor 11
- HGNC 11811(opens in a new tab)
- Ensembl gene ENSG00000172059(opens in a new tab)
- NCBI Gene 8462(opens in a new tab)
Summary
- Cytogenetic location
- 2p25.1
- Coordinates
- Chromosome 2: 10,043,550–10,054,836 (GRCh38)
- Exons
- 4 exons across 11.3 kb
- Protein
- 512 amino acids
- Inheritance
- Autosomal dominant
- Also known as
- Tieg3, MODY7, FKLF
- Previous symbols
- TIEG2
- MANE Select transcript
- ENST00000305883.6NM_003597.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome TestCurated reports relevant to this gene
Diabetes Mellitus
A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.
- 1 GenCC submitter rates it definitive or strong
What knowing changes
Teplizumab (Tzield) for stage 2 presymptomatic T1D (FDA approved 2022); insulin replacement at clinical T1D onset; TrialNet autoantibody screening for high-risk relatives; closed-loop insulin delivery systems
Maturity-Onset Diabetes Of The Young
- Autosomal dominant
MODY (maturity-onset diabetes of the young) is a rare, familial, clinically and genetically heterogeneous form of diabetes characterized by young age of onset (generally 10-45 years of age) with maintenance of endogenous insulin production, lack of pancreatic beta-cell autoimmunity, absence of obesity and insulin resistance and extra-pancreatic manifestations in some subtypes.
- 1 GenCC submitter rates it definitive or strong
What knowing changes
GCK-MODY: no treatment needed; HNF1A/HNF4A-MODY: low-dose sulfonylureas; HNF1B-MODY: insulin + renal monitoring; T2D polygenic: lifestyle modification, metformin, GLP-1 agonists, SGLT2 inhibitors based on comorbidity profile
Inheritance
- Autosomal dominant
- One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
How KLF11 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4 kb of the gene's 11.3 kb; 1,539 of those bases code for the protein.
Traits linked to KLF11
The Human Phenotype Ontology lists these as features of the rare conditions KLF11 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). KLF11 gene: KLF transcription factor 11. Retrieved 16 October 2026, from https://dantelabs.com/genes/klf11
Dante Labs. KLF11 gene: KLF transcription factor 11 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/klf11
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