Trait
Abnormal kidney function
Clinical name: Abnormal renal physiology
An abnormal functionality of the kidney.
Summary
- Also called
- Kidney function issue, Abnormal renal function, Abnormality of renal physiology, Renal functional abnormality
- Body system
- Abnormality of the genitourinary system
Reference genomeGRCh38hg38
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Get my Genome Test17 genes linked to Abnormal kidney function
Changes in these genes cause rare conditions in which Abnormal kidney function is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| HOGA14-hydroxy-2-oxoglutarate aldolase 1 | Very often (80–99%) | In 1 condition |
| MYO5Bmyosin VB | Often (30–79%) | In 1 condition |
| PRF1perforin 1 | Often (30–79%) | In 1 condition |
| SLC22A12solute carrier family 22 member 12 | Often (30–79%) | In 1 condition |
| SLC2A9solute carrier family 2 member 9 | Often (30–79%) | In 1 condition |
| STX11syntaxin 11 | Often (30–79%) | In 1 condition |
| STX3syntaxin 3 | Often (30–79%) | In 1 condition |
| STXBP2syntaxin binding protein 2 | Often (30–79%) | In 1 condition |
| TTRtransthyretin | Often (30–79%) | In 1 condition |
| UNC13Dunc-13 homolog D | Often (30–79%) | In 1 condition |
| CDK4cyclin dependent kinase 4 | Sometimes (5–29%) | In 1 condition |
| HMGA2high mobility group AT-hook 2 | Sometimes (5–29%) | In 1 condition |
| MDM2MDM2 proto-oncogene | Sometimes (5–29%) | In 1 condition |
| PEX7peroxisomal biogenesis factor 7 | Sometimes (5–29%) | In 1 condition |
| PHYHphytanoyl-CoA 2-hydroxylase | Sometimes (5–29%) | In 1 condition |
| ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif 13 | Not recorded | In 1 condition |
| ELP1elongator acetyltransferase complex subunit 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Renal failure312 genes
- Blood in urine163 genes
- Nephrotic syndrome125 genes
- Kidney damage103 genes
- Abnormal function of filtrating structures in kidney34 genes
- Renovascular hypertension28 genes
- Kidney inflammation24 genes
- Hemolytic-uremic syndrome17 genes
- Abnormality of renal excretion2 genes
- Impaired urinary acidification1 gene
- Isothenuria1 gene
- Abnormal glomerular filtration rate
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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