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Gene

SLC5A2

solute carrier family 5 member 2

Summary

Cytogenetic location
16p11.2
Coordinates
Chromosome 16: 31,483,123–31,490,769 (GRCh38)
Exons
14 exons across 7.6 kb
Protein
672 amino acids
Previous symbols
SGLT2
MANE Select transcript
ENST00000330498.4NM_003041.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Fanconi Renotubular Syndrome and Renal Glucosuria

    • Familial Renal Glucosuria

      Glucose in the urine despite normal blood sugar, caused by SLC5A2 variants; it is generally benign.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing explains glucose found on urine tests and avoids an incorrect diabetes diagnosis.

How SLC5A2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 16, with a bracket where SLC5A2 sits. SLC5A2 and 27 genes near it on chromosome 16, from 30,986,946 to 31,986,945.Chromosome 1616p11.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.331 Mb31.2 Mb31.4 Mb31.6 Mb31.8 MbHSD3B7: 30,985,029–30,989,154, forward strandHSD3B7STX1B: 30,989,256–31,010,897, reverse strandSTX1BSTX4: 31,032,889–31,042,975, forward strandSTX4ZNF668: 31,059,772–31,074,240, reverse strandZNF646: 31,074,394–31,084,196, forward strandPRSS53: 31,083,437–31,089,628, reverse strand: 31,083,439–31,094,956, reverse strandVKORC1: 31,090,260–31,095,980, reverse strandBCKDK: 31,106,107–31,113,464, forward strandBCKDKKAT8: 31,114,489–31,131,396, forward strandKAT8PRSS8: 31,131,433–31,135,727, reverse strandPRSS8PRSS36: 31,138,926–31,150,213, reverse strandPRSS36FUS: 31,180,131–31,196,963, forward strandFUSPYCARD: 31,201,486–31,203,450, reverse strandPYCARDTRIM72: 31,214,017–31,231,537, forward strandTRIM72PYDC1: 31,215,962–31,217,162, reverse strandPYDC1ITGAM: 31,259,954–31,332,892, forward strandITGAMITGAX: 31,355,134–31,382,999, forward strandITGAXITGAD: 31,393,258–31,426,505, forward strandITGADCOX6A2: 31,427,731–31,428,433, reverse strandZNF843: 31,432,593–31,444,323, reverse strandZNF843ARMC5: 31,458,080–31,467,172, forward strandARMC5TGFB1I1: 31,471,585–31,478,727, forward strandTGFB1I1SLC5A2: 31,483,123–31,490,769, forward strandSLC5A2RUSF1: 31,489,465–31,509,309, reverse strandRUSF1AHSP: 31,512,938–31,528,808, forward strandAHSPKRABD5: 31,713,227–31,794,890, forward strandKRABD5ZNF267: 31,873,783–31,918,055, forward strandZNF267Diagram of SLC5A2: 14 exons on the forward strand of chromosome 16Exon 3: 2 known disease-causing sitesExon 4: 6 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 11: 5 known disease-causing sitesExon 12: 6 known disease-causing sitesExon 13: 1 known disease-causing siteExon 14: 2 known disease-causing sitesExon 1: 31,483,123–31,483,262, 140 basesExon 2: 31,484,673–31,484,744, 72 basesExon 3: 31,484,819–31,484,923, 105 basesExon 4: 31,485,729–31,485,893, 165 basesExon 5: 31,486,170–31,486,275, 106 basesExon 6: 31,487,320–31,487,400, 81 basesExon 7: 31,487,530–31,487,759, 230 basesExon 8: 31,488,038–31,488,173, 136 basesExon 9: 31,488,383–31,488,490, 108 basesExon 10: 31,488,622–31,488,772, 151 basesExon 11: 31,488,880–31,489,048, 169 basesExon 12: 31,489,123–31,489,338, 216 basesExon 13: 31,490,104–31,490,230, 127 basesExon 14: 31,490,309–31,490,769, 461 bases12345678910111213145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 7.6 kb; 2,019 of those bases code for the protein.

How a genome test reads SLC5A2

45

positions in SLC5A2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.6 kb of SLC5A2, introns included, not only the 2.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC5A2 gene: solute carrier family 5 member 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/slc5a2

Vancouver

Dante Labs. SLC5A2 gene: solute carrier family 5 member 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/slc5a2

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