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Gene

FOXI1

forkhead box I1

Summary

Cytogenetic location
5q35.1
Coordinates
Chromosome 5: 170,105,897–170,109,734 (GRCh38)
Exons
2 exons across 3.8 kb
Protein
378 amino acids
Inheritance
Autosomal recessive
Also known as
FREAC6
Previous symbols
FKHL10
MANE Select transcript
ENST00000306268.8NM_012188.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Renal Tubular Acidosis

    • Distal Renal Tubular AcidosisAutosomal recessive

      An inherited inability of the kidney's collecting ducts to excrete acid, caused by variants in SLC4A1, ATP6V1B1, ATP6V0A4 and other genes; some forms also cause hearing loss.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Alkali treatment can prevent kidney calcification and growth problems, and some forms warrant a hearing assessment.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How FOXI1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 5, with a bracket where FOXI1 sits. FOXI1 and 6 genes near it on chromosome 5, from 169,607,816 to 170,607,815.Chromosome 55q35.1p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3169.8 Mb170 Mb170.2 Mb170.4 Mb170.6 MbDOCK2: 169,637,224–170,083,382, forward strandDOCK2INSYN2B: 169,861,303–169,980,507, reverse strandINSYN2BFOXI1: 170,105,897–170,109,734, forward strandFOXI1C5orf58: 170,228,881–170,252,575, forward strandC5orf58LCP2: 170,246,233–170,297,845, reverse strandLCP2KCNIP1: 170,353,487–170,736,632, forward strandKCNIP1KCNMB1: 170,364,749–170,480,428, reverse strandKCNMB1Diagram of FOXI1: 2 exons on the forward strand of chromosome 5Exon 1: 2 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 1: 170,105,897–170,106,531, 635 basesExon 2: 170,108,049–170,109,734, 1,686 bases125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 3.8 kb; 1,137 of those bases code for the protein.

How a genome test reads FOXI1

5

positions in FOXI1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.8 kb of FOXI1, introns included, not only the 2.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FOXI1 gene: forkhead box I1. Retrieved 16 October 2026, from https://dantelabs.com/genes/foxi1

Vancouver

Dante Labs. FOXI1 gene: forkhead box I1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/foxi1

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