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Gene

EMC1

ER membrane protein complex subunit 1

Summary

Cytogenetic location
1p36.13
Coordinates
Chromosome 1: 19,215,660–19,251,524 (GRCh38)
Exons
23 exons across 35.9 kb
Protein
993 amino acids
Previous symbols
KIAA0090
MANE Select transcript
ENST00000477853.6NM_015047.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads EMC1 yet. The test sequences your whole genome, so your data includes it all the same.

How EMC1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where EMC1 sits. EMC1 and 16 genes near it on chromosome 1, from 18,733,592 to 19,733,591.Chromosome 11p36.13p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4418.8 Mb19 Mb19.2 Mb19.4 Mb19.6 MbPAX7: 18,630,846–18,748,876, forward strandPAX7TAS1R2: 18,839,599–18,859,660, reverse strandTAS1R2ALDH4A1: 18,871,425–18,902,799, reverse strandALDH4A1IFFO2: 18,904,280–18,956,676, reverse strandIFFO2UBR4: 19,074,510–19,210,329, reverse strandUBR4EMC1: 19,215,660–19,251,524, reverse strandEMC1MRTO4: 19,251,555–19,260,128, forward strandMRTO4AKR7L: 19,265,982–19,274,194, reverse strandAKR7LAKR7A3: 19,281,056–19,288,823, reverse strandAKR7A3SLC66A1: 19,288,044–19,332,427, forward strandAKR7A2: 19,291,523–19,312,149, reverse strandAKR7A2CAPZB: 19,338,775–19,485,650, reverse strandCAPZBMICOS10: 19,484,403–19,629,821, forward strandMICOS10NBL1: 19,596,979–19,659,413, forward strandNBL1MICOS10-NBL1: 19,597,067–19,656,927, forward strandMICOS10-NBL1HTR6: 19,664,837–19,680,966, forward strandHTR6TMCO4: 19,682,207–19,800,500, reverse strandTMCO4Diagram of EMC1: 23 exons on the reverse strand of chromosome 1Exon 22: 3 known disease-causing sitesExon 19: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 15: 3 known disease-causing sitesExon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 23: 19,215,660–19,219,482, 3,823 basesExon 22: 19,219,569–19,219,698, 130 basesExon 21: 19,220,764–19,220,848, 85 basesExon 20: 19,222,624–19,222,834, 211 basesExon 19: 19,223,396–19,223,569, 174 basesExon 18: 19,227,313–19,227,450, 138 basesExon 17: 19,230,844–19,230,963, 120 basesExon 16: 19,231,261–19,231,422, 162 basesExon 15: 19,232,624–19,232,773, 150 basesExon 14: 19,232,936–19,233,135, 200 basesExon 13: 19,235,130–19,235,252, 123 basesExon 12: 19,237,142–19,237,238, 97 basesExon 11: 19,238,017–19,238,139, 123 basesExon 10: 19,238,795–19,238,857, 63 basesExon 9: 19,239,231–19,239,302, 72 basesExon 8: 19,239,818–19,239,985, 168 basesExon 7: 19,240,297–19,240,446, 150 basesExon 6: 19,241,016–19,241,142, 127 basesExon 5: 19,242,345–19,242,473, 129 basesExon 4: 19,243,614–19,243,707, 94 basesExon 3: 19,243,950–19,244,015, 66 basesExon 2: 19,244,906–19,245,030, 125 basesExon 1: 19,251,415–19,251,524, 110 bases2322201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.6 kb of the gene's 35.9 kb; 2,982 of those bases code for the protein.

How a genome test reads EMC1

22

positions in EMC1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 35.9 kb of EMC1, introns included, not only the 6.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). EMC1 gene: ER membrane protein complex subunit 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/emc1

Vancouver

Dante Labs. EMC1 gene: ER membrane protein complex subunit 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/emc1

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