Gene
BRWD1
bromodomain and WD repeat domain containing 1
- HGNC 12760(opens in a new tab)
- Ensembl gene ENSG00000185658(opens in a new tab)
- NCBI Gene 54014(opens in a new tab)
Summary
- Cytogenetic location
- 21q22.2
- Coordinates
- Chromosome 21: 39,185,482–39,313,632 (GRCh38)
- Exons
- 41 exons across 128.2 kb
- Protein
- 2,269 amino acids
- Also known as
- FLJ11315, N143, DCAF19
- Previous symbols
- C21orf107, WDR9
- MANE Select transcript
- ENST00000342449.8NM_033656.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads BRWD1 yet. The test sequences your whole genome, so your data includes it all the same.
How BRWD1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 17.7 kb of the gene's 128.2 kb; 6,810 of those bases code for the protein.
How a genome test reads BRWD1
1
position in BRWD1 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 128.2 kb of BRWD1, introns included, not only the 17.7 kb of exons.
Traits linked to BRWD1
The Human Phenotype Ontology lists these as features of the rare conditions BRWD1 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the genitourinary system
- Absent sperm flagella
- Irregularly shaped sperm tail
- Male infertility
- Reduced progressive sperm motility
- Reduced sperm motility
- Short sperm flagella
- Abnormal sperm motility
- Low sperm count
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). BRWD1 gene: bromodomain and WD repeat domain containing 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/brwd1
Dante Labs. BRWD1 gene: bromodomain and WD repeat domain containing 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/brwd1
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