Skip to content
Use your HSA or FSA funds

Gene

DAW1

dynein assembly factor with WD repeats 1

Summary

Cytogenetic location
2q36.3
Coordinates
Chromosome 2: 227,871,631–227,924,344 (GRCh38)
Exons
13 exons across 52.7 kb
Protein
415 amino acids
Inheritance
Autosomal recessive
Also known as
FLJ25955, ODA16, DNAAF18
Previous symbols
WDR69
MANE Select transcript
ENST00000309931.3NM_178821.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Heterotaxy & Laterality Defects

    • Visceral Heterotaxy

      Abnormal left-right arrangement of the internal organs, caused by changes in genes such as ZIC3 (X-linked), NODAL, CFC1, MMP21 and PKD1L1, often with complex heart defects and spleen abnormalities.

      • ClinGen rates the link moderate
      What knowing changes

      Knowing about it supports heart and abdominal imaging, infection precautions if the spleen is absent, and reproductive counselling.

  • Primary Ciliary Dyskinesia

    • Autosomal recessive

      A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How DAW1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where DAW1 sits. DAW1 and 12 genes near it on chromosome 2, from 227,397,988 to 228,397,987.Chromosome 22q36.3p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3227.4 Mb227.6 Mb227.8 Mb228 Mb228.2 MbAGFG1: 227,472,134–227,561,411, forward strandAGFG1SCYGR2: 227,598,893–227,599,255, forward strandSCYGR2SCYGR10: 227,608,784–227,609,101, forward strandSCYGR10SCYGR3: 227,614,538–227,614,840, reverse strandSCYGR3SCYGR4: 227,617,498–227,617,815, forward strandSCYGR4SCYGR5: 227,666,804–227,667,061, forward strandSCYGR5SLC19A3: 227,683,763–227,718,088, reverse strandSLC19A3SCYGR6: 227,724,440–227,724,757, reverse strandSCYGR6SCYGR7: 227,728,335–227,728,625, forward strandSCYGR7SCYGR8: 227,745,894–227,746,220, forward strandSCYGR8CCL20: 227,805,739–227,817,564, forward strandCCL20DAW1: 227,871,631–227,924,344, forward strandDAW1SPHKAP: 227,979,866–228,182,020, reverse strandSPHKAPDiagram of DAW1: 13 exons on the forward strand of chromosome 2Exon 9: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 1: 227,871,631–227,871,729, 99 basesExon 2: 227,885,351–227,885,423, 73 basesExon 3: 227,889,856–227,890,000, 145 basesExon 4: 227,891,255–227,891,313, 59 basesExon 5: 227,893,795–227,893,917, 123 basesExon 6: 227,898,182–227,898,281, 100 basesExon 7: 227,903,002–227,903,109, 108 basesExon 8: 227,904,929–227,905,035, 107 basesExon 9: 227,906,236–227,906,338, 103 basesExon 10: 227,907,138–227,907,252, 115 basesExon 11: 227,918,780–227,918,856, 77 basesExon 12: 227,921,399–227,921,561, 163 basesExon 13: 227,923,934–227,924,344, 411 bases124681012135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 52.7 kb; 1,248 of those bases code for the protein.

How a genome test reads DAW1

2

positions in DAW1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 52.7 kb of DAW1, introns included, not only the 1.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DAW1 gene: dynein assembly factor with WD repeats 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/daw1

Vancouver

Dante Labs. DAW1 gene: dynein assembly factor with WD repeats 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/daw1

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test