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Gene

TP73

tumor protein p73

Summary

Cytogenetic location
1p36.32
Coordinates
Chromosome 1: 3,652,516–3,736,201 (GRCh38)
Exons
14 exons across 83.7 kb
Protein
636 amino acids
Inheritance
Autosomal recessive
Also known as
P73
MANE Select transcript
ENST00000378295.9NM_005427.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Ciliary Dyskinesia

    • Autosomal recessive

      A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).

      • ClinGen rates the link strong
      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How TP73 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where TP73 sits. TP73 and 11 genes near it on chromosome 1, from 3,194,359 to 4,194,358.Chromosome 11p36.32p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q443.2 Mb3.4 Mb3.6 Mb3.8 Mb4 MbPRDM16: 3,069,003–3,438,621, forward strandPRDM16ARHGEF16: 3,454,550–3,485,968, forward strandARHGEF16MEGF6: 3,487,942–3,611,543, reverse strandMEGF6TPRG1L: 3,624,979–3,630,131, forward strandTPRG1LWRAP73: 3,630,767–3,652,761, reverse strandWRAP73TP73: 3,652,516–3,736,201, forward strandTP73CCDC27: 3,746,460–3,771,645, forward strandCCDC27SMIM1: 3,772,648–3,782,178, forward strandSMIM1LRRC47: 3,778,559–3,796,517, reverse strandLRRC47CEP104: 3,812,086–3,857,723, reverse strandCEP104DFFB: 3,857,242–3,885,491, forward strandDFFBC1orf174: 3,889,125–3,900,297, reverse strandC1orf174Diagram of TP73: 14 exons on the forward strand of chromosome 1Exon 5: 2 known disease-causing sitesExon 1: 3,652,516–3,652,641, 126 basesExon 2: 3,682,333–3,682,430, 98 basesExon 3: 3,683,060–3,683,180, 121 basesExon 4: 3,707,549–3,707,791, 243 basesExon 5: 3,722,021–3,722,207, 187 basesExon 6: 3,723,354–3,723,469, 116 basesExon 7: 3,727,115–3,727,224, 110 basesExon 8: 3,727,628–3,727,770, 143 basesExon 9: 3,728,129–3,728,217, 89 basesExon 10: 3,729,327–3,729,448, 122 basesExon 11: 3,730,000–3,730,148, 149 basesExon 12: 3,730,927–3,731,065, 139 basesExon 13: 3,731,463–3,731,556, 94 basesExon 14: 3,732,747–3,736,201, 3,455 bases1510145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.2 kb of the gene's 83.7 kb; 1,911 of those bases code for the protein.

How a genome test reads TP73

3

positions in TP73 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 83.7 kb of TP73, introns included, not only the 5.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TP73 gene: tumor protein p73. Retrieved 16 October 2026, from https://dantelabs.com/genes/tp73

Vancouver

Dante Labs. TP73 gene: tumor protein p73 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tp73

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