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Gene

CFAP74

cilia and flagella associated protein 74

Summary

Cytogenetic location
1p36.33
Coordinates
Chromosome 1: 1,921,957–2,003,786 (GRCh38)
Exons
39 exons across 81.8 kb
Protein
1,639 amino acids
Also known as
FLJ45476
Previous symbols
C1orf222, KIAA1751
MANE Select transcript
ENST00000682832.2NM_001304360.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CFAP74 yet. The test sequences your whole genome, so your data includes it all the same.

How CFAP74 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where CFAP74 sits. CFAP74 and 23 genes near it on chromosome 1, from 1,462,872 to 2,462,871.Chromosome 11p36.33p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q441.6 Mb1.8 Mb2 Mb2.2 Mb2.4 MbATAD3C: 1,449,689–1,470,163, forward strandATAD3CATAD3B: 1,471,742–1,497,848, forward strandATAD3BATAD3A: 1,512,118–1,534,689, forward strandATAD3ATMEM240: 1,534,778–1,540,624, reverse strandTMEM240SSU72: 1,541,673–1,574,887, reverse strandSSU72FNDC10: 1,598,012–1,600,135, reverse strandFNDC10MIB2: 1,615,433–1,630,610, forward strandMIB2MMP23B: 1,631,660–1,635,263, forward strandMMP23BCDK11B: 1,635,225–1,659,267, reverse strandCDK11BSLC35E2B: 1,659,529–1,693,059, reverse strandSLC35E2BCDK11A: 1,702,379–1,724,571, reverse strandCDK11ANADK: 1,751,232–1,780,544, reverse strandNADKGNB1: 1,785,285–1,892,292, reverse strandGNB1CALML6: 1,915,081–1,917,296, forward strandCALML6TMEM52: 1,917,589–1,919,329, reverse strandTMEM52CFAP74: 1,921,957–2,003,786, reverse strandCFAP74GABRD: 2,019,305–2,030,758, forward strandGABRDPRKCZ: 2,050,396–2,185,721, forward strandPRKCZFAAP20: 2,184,411–2,212,720, reverse strandFAAP20SKI: 2,227,388–2,310,213, forward strandSKIMORN1: 2,319,208–2,391,722, reverse strandMORN1RER1: 2,390,670–2,405,444, forward strandRER1PEX10: 2,403,784–2,413,797, reverse strandPEX10PLCH2: 2,425,980–2,505,807, forward strandPLCH2Diagram of CFAP74: 39 exons on the reverse strand of chromosome 1Exon 35: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 39: 1,921,957–1,922,388, 432 basesExon 38: 1,922,589–1,922,723, 135 basesExon 37: 1,922,985–1,923,145, 161 basesExon 36: 1,923,367–1,923,499, 133 basesExon 35: 1,923,775–1,923,929, 155 basesExon 34: 1,924,391–1,924,520, 130 basesExon 33: 1,925,783–1,925,938, 156 basesExon 32: 1,926,228–1,926,347, 120 basesExon 31: 1,926,457–1,926,512, 56 basesExon 30: 1,926,652–1,926,761, 110 basesExon 29: 1,926,894–1,927,028, 135 basesExon 28: 1,927,607–1,927,746, 140 basesExon 27: 1,928,784–1,928,882, 99 basesExon 26: 1,930,060–1,930,336, 277 basesExon 25: 1,938,855–1,938,988, 134 basesExon 24: 1,939,594–1,939,767, 174 basesExon 23: 1,940,316–1,940,403, 88 basesExon 22: 1,942,028–1,942,156, 129 basesExon 21: 1,944,331–1,944,452, 122 basesExon 20: 1,946,317–1,946,439, 123 basesExon 19: 1,946,990–1,947,054, 65 basesExon 18: 1,955,691–1,955,850, 160 basesExon 17: 1,956,620–1,956,784, 165 basesExon 16: 1,959,120–1,959,209, 90 basesExon 15: 1,959,964–1,960,030, 67 basesExon 14: 1,963,749–1,963,867, 119 basesExon 13: 1,964,888–1,965,061, 174 basesExon 12: 1,966,371–1,966,526, 156 basesExon 11: 1,968,635–1,968,833, 199 basesExon 10: 1,970,659–1,970,816, 158 basesExon 9: 1,971,980–1,972,082, 103 basesExon 8: 1,972,937–1,973,047, 111 basesExon 7: 1,974,025–1,974,198, 174 basesExon 6: 1,985,386–1,985,490, 105 basesExon 5: 1,986,937–1,987,035, 99 basesExon 4: 1,988,512–1,988,655, 144 basesExon 3: 1,988,889–1,988,973, 85 basesExon 2: 1,990,890–1,990,975, 86 basesExon 1: 2,003,701–2,003,786, 86 bases3930201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.4 kb of the gene's 81.8 kb; 4,920 of those bases code for the protein.

How a genome test reads CFAP74

6

positions in CFAP74 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 81.8 kb of CFAP74, introns included, not only the 5.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CFAP74 gene: cilia and flagella associated protein 74. Retrieved 16 October 2026, from https://dantelabs.com/genes/cfap74

Vancouver

Dante Labs. CFAP74 gene: cilia and flagella associated protein 74 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cfap74

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