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Gene

GAS2L2

growth arrest specific 2 like 2

Summary

Cytogenetic location
17q12
Coordinates
Chromosome 17: 35,744,511–35,753,239 (GRCh38)
Exons
6 exons across 8.7 kb
Protein
880 amino acids
Inheritance
Autosomal recessive
Also known as
GAR17
MANE Select transcript
ENST00000604641.6NM_139285.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Ciliary Dyskinesia

    • Autosomal recessive

      A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How GAS2L2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 17, with a bracket where GAS2L2 sits. GAS2L2 and 27 genes near it on chromosome 17, from 35,248,875 to 36,248,874.Chromosome 1717q12p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.335.4 Mb35.6 Mb35.8 Mb36 Mb36.2 MbSLFN5: 35,243,043–35,273,655, forward strandSLFN5SLFN11: 35,350,305–35,373,701, reverse strandSLFN11SLFN12: 35,409,339–35,433,475, reverse strandSLFN12SLFN13: 35,435,096–35,449,766, reverse strandSLFN13SLFN12L: 35,464,249–35,537,770, reverse strandSLFN12LSLFN14: 35,543,985–35,560,819, reverse strandSLFN14PEX12: 35,574,795–35,578,863, reverse strandPEX12AP2B1: 35,578,046–35,726,417, forward strandAP2B1RASL10B: 35,731,639–35,743,521, forward strandRASL10BGAS2L2: 35,744,511–35,753,239, reverse strandGAS2L2MMP28: 35,756,249–35,795,719, reverse strandMMP28PGBDF: 35,760,887–35,765,079, forward strandPGBDFTAF15: 35,809,475–35,864,615, forward strandTAF15HEATR9: 35,854,946–35,868,891, reverse strandHEATR9CCL5: 35,871,491–35,880,793, reverse strandCCL5RDM1: 35,918,066–35,930,794, reverse strandRDM1LYZL6: 35,934,518–35,943,713, reverse strandLYZL6CCL16: 35,976,192–35,981,580, reverse strandCCL16CCL14: 35,983,288–35,987,033, reverse strandCCL14CCL15-CCL14: 35,983,656–36,001,621, reverse strandCCL15-CCL14CCL15: 35,988,463–36,002,119, reverse strandCCL15CCL23: 36,013,056–36,017,979, reverse strandCCL18: 36,064,228–36,072,032, forward strandCCL18CCL3: 36,088,256–36,090,169, reverse strandCCL3CCL4: 36,103,588–36,105,627, forward strandCCL4TBC1D3B: 36,165,683–36,176,636, reverse strandTBC1D3BCCL3L3: 36,194,869–36,196,758, reverse strandCCL3L3CCL4L2: 36,210,924–36,212,878, forward strandCCL4L2Diagram of GAS2L2: 6 exons on the reverse strand of chromosome 17Exon 6: 35,744,511–35,746,411, 1,901 basesExon 5: 35,747,016–35,747,268, 253 basesExon 4: 35,747,849–35,747,945, 97 basesExon 3: 35,749,110–35,749,217, 108 basesExon 2: 35,750,077–35,750,318, 242 basesExon 1: 35,752,466–35,753,239, 774 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.4 kb of the gene's 8.7 kb; 2,643 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GAS2L2 gene: growth arrest specific 2 like 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/gas2l2

Vancouver

Dante Labs. GAS2L2 gene: growth arrest specific 2 like 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gas2l2

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