Traits

Traits linked to WSB2

WD repeat and SOCS box containing 2

The Human Phenotype Ontology links 83 traits to WSB2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	Kaip dažnai pasireiškia
Abnormal anterior horn cell morphology	Visada
Abnormal gait	Visada
Absent speech development	Visada
Attention deficit	Visada
Colpocephaly	Visada
Delayed fine motor development	Visada
Delayed speech and language development	Visada
Fewer and broader ridges in brain	Visada
Global developmental delay	Visada
Gray matter heterotopia	Visada
Happy demeanor	Visada
Intellectual disability	Visada
IQ between 34 and 49	Visada
Lethargy	Visada
Obstructive sleep apnea	Visada
Poor eye contact	Visada
Delayed motor skills	Labai dažnai (80–99%)
Autism	Dažnai (30–79%)
Brisk reflexes	Dažnai (30–79%)
Cerebellar vermis hypoplasia	Dažnai (30–79%)
Epilepsy	Dažnai (30–79%)
Recurrent hand flapping	Dažnai (30–79%)
Small cerebellum	Dažnai (30–79%)
Underdevelopment of part of brain called corpus callosum	Dažnai (30–79%)
Chorea	Kartais (5–29%)
CNS hypomyelination	Kartais (5–29%)
Degeneration of cerebellum	Kartais (5–29%)
Hypoplasia of the olfactory bulb	Kartais (5–29%)
Simplified gyral pattern	Kartais (5–29%)
Small hippocampus	Kartais (5–29%)
Thin corpus callosum	Kartais (5–29%)

Abnormality of head or neck

Trait	Kaip dažnai pasireiškia
Small forehead	Visada
Small head present at birth	Visada
Upward slanting of the opening between the eyelids	Visada
Abnormally small head	Dažnai (30–79%)
High palate	Dažnai (30–79%)
Little lower jaw	Dažnai (30–79%)
Long face	Kartais (5–29%)
Low frontal hairline	Kartais (5–29%)
Narrow forehead	Kartais (5–29%)
Receding chin	Kartais (5–29%)

Abnormality of the eye

Trait	Kaip dažnai pasireiškia
Asymmetric pupil sizes	Visada
Congenital drooping upper eyelid	Visada
Involuntary, rapid, rhythmic eye movements	Visada
Deeply set eye	Dažnai (30–79%)
Farsightedness	Dažnai (30–79%)
Bulging eye	Kartais (5–29%)
Cerebral visual impairment	Kartais (5–29%)
Inward turning cross eyed	Kartais (5–29%)
Optic nerve hypoplasia	Kartais (5–29%)
Wide-set eyes	Kartais (5–29%)

Abnormality of limbs

Trait	Kaip dažnai pasireiškia
Dropped arches	Visada
Ulnar deviation of the hand	Visada
High-arched foot	Dažnai (30–79%)
Overlapping toe	Dažnai (30–79%)
Curvature of little finger	Kartais (5–29%)
Permanent flexion of the finger	Kartais (5–29%)
Talipes	Kartais (5–29%)

Abnormality of the musculoskeletal system

Trait	Kaip dažnai pasireiškia
Double-Jointed	Visada
EMG: neuropathic changes	Visada
Fiber type grouping	Visada
Generalized decreased muscle tone	Visada
Low muscle tone	Visada
Type 1 muscle fiber predominance	Visada

Abnormality of the digestive system

Trait	Kaip dažnai pasireiškia
Gastrostomy tube feeding in infancy	Visada
Nasogastric tube feeding	Visada
Constipation	Kartais (5–29%)
Poor swallowing	Kartais (5–29%)

Abnormality of the ear

Trait	Kaip dažnai pasireiškia
Large earlobe	Visada
Large ears	Dažnai (30–79%)
Simple ear	Kartais (5–29%)

Growth abnormality

Trait	Kaip dažnai pasireiškia
Faltering weight	Dažnai (30–79%)
Prenatal growth deficiency	Dažnai (30–79%)
Small for gestational age	Dažnai (30–79%)

Abnormality of prenatal development or birth

Trait	Kaip dažnai pasireiškia
Induced vaginal delivery	Visada
Low levels of amniotic fluid	Kartais (5–29%)

Abnormality of the cardiovascular system

Trait	Kaip dažnai pasireiškia
Mobitz I atrioventricular block	Visada
Hole in heart wall separating two lower heart chambers	Kartais (5–29%)

Abnormality of the respiratory system

Trait	Kaip dažnai pasireiškia
Apneic episodes in infancy	Visada
Aspiration	Visada

Abnormality of the breast

Trait	Kaip dažnai pasireiškia
Wide-spaced nipples	Kartais (5–29%)

Abnormality of the genitourinary system

Trait	Kaip dažnai pasireiškia
Duplicated collecting system	Kartais (5–29%)

Laboratory abnormality

Trait	Kaip dažnai pasireiškia
High urine protein levels	Visada

Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.

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The Human Phenotype Ontology, release 2026-09-01: the traits linked to WSB2 and how often each is seen. Find out more at hpo.jax.org.

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