Traits

Traits linked to WSB2

WD repeat and SOCS box containing 2

The Human Phenotype Ontology links 83 traits to WSB2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	Hvor ofte den forekommer
Abnormal anterior horn cell morphology	Alltid
Abnormal gait	Alltid
Absent speech development	Alltid
Attention deficit	Alltid
Colpocephaly	Alltid
Delayed fine motor development	Alltid
Delayed speech and language development	Alltid
Fewer and broader ridges in brain	Alltid
Global developmental delay	Alltid
Gray matter heterotopia	Alltid
Happy demeanor	Alltid
Intellectual disability	Alltid
IQ between 34 and 49	Alltid
Lethargy	Alltid
Obstructive sleep apnea	Alltid
Poor eye contact	Alltid
Delayed motor skills	Svært ofte (80–99 %)
Autism	Ofte (30–79 %)
Brisk reflexes	Ofte (30–79 %)
Cerebellar vermis hypoplasia	Ofte (30–79 %)
Epilepsy	Ofte (30–79 %)
Recurrent hand flapping	Ofte (30–79 %)
Small cerebellum	Ofte (30–79 %)
Underdevelopment of part of brain called corpus callosum	Ofte (30–79 %)
Chorea	Noen ganger (5–29 %)
CNS hypomyelination	Noen ganger (5–29 %)
Degeneration of cerebellum	Noen ganger (5–29 %)
Hypoplasia of the olfactory bulb	Noen ganger (5–29 %)
Simplified gyral pattern	Noen ganger (5–29 %)
Small hippocampus	Noen ganger (5–29 %)
Thin corpus callosum	Noen ganger (5–29 %)

Abnormality of head or neck

Trait	Hvor ofte den forekommer
Small forehead	Alltid
Small head present at birth	Alltid
Upward slanting of the opening between the eyelids	Alltid
Abnormally small head	Ofte (30–79 %)
High palate	Ofte (30–79 %)
Little lower jaw	Ofte (30–79 %)
Long face	Noen ganger (5–29 %)
Low frontal hairline	Noen ganger (5–29 %)
Narrow forehead	Noen ganger (5–29 %)
Receding chin	Noen ganger (5–29 %)

Abnormality of the eye

Trait	Hvor ofte den forekommer
Asymmetric pupil sizes	Alltid
Congenital drooping upper eyelid	Alltid
Involuntary, rapid, rhythmic eye movements	Alltid
Deeply set eye	Ofte (30–79 %)
Farsightedness	Ofte (30–79 %)
Bulging eye	Noen ganger (5–29 %)
Cerebral visual impairment	Noen ganger (5–29 %)
Inward turning cross eyed	Noen ganger (5–29 %)
Optic nerve hypoplasia	Noen ganger (5–29 %)
Wide-set eyes	Noen ganger (5–29 %)

Abnormality of limbs

Trait	Hvor ofte den forekommer
Dropped arches	Alltid
Ulnar deviation of the hand	Alltid
High-arched foot	Ofte (30–79 %)
Overlapping toe	Ofte (30–79 %)
Curvature of little finger	Noen ganger (5–29 %)
Permanent flexion of the finger	Noen ganger (5–29 %)
Talipes	Noen ganger (5–29 %)

Abnormality of the musculoskeletal system

Trait	Hvor ofte den forekommer
Double-Jointed	Alltid
EMG: neuropathic changes	Alltid
Fiber type grouping	Alltid
Generalized decreased muscle tone	Alltid
Low muscle tone	Alltid
Type 1 muscle fiber predominance	Alltid

Abnormality of the digestive system

Trait	Hvor ofte den forekommer
Gastrostomy tube feeding in infancy	Alltid
Nasogastric tube feeding	Alltid
Constipation	Noen ganger (5–29 %)
Poor swallowing	Noen ganger (5–29 %)

Abnormality of the ear

Trait	Hvor ofte den forekommer
Large earlobe	Alltid
Large ears	Ofte (30–79 %)
Simple ear	Noen ganger (5–29 %)

Growth abnormality

Trait	Hvor ofte den forekommer
Faltering weight	Ofte (30–79 %)
Prenatal growth deficiency	Ofte (30–79 %)
Small for gestational age	Ofte (30–79 %)

Abnormality of prenatal development or birth

Trait	Hvor ofte den forekommer
Induced vaginal delivery	Alltid
Low levels of amniotic fluid	Noen ganger (5–29 %)

Abnormality of the cardiovascular system

Trait	Hvor ofte den forekommer
Mobitz I atrioventricular block	Alltid
Hole in heart wall separating two lower heart chambers	Noen ganger (5–29 %)

Abnormality of the respiratory system

Trait	Hvor ofte den forekommer
Apneic episodes in infancy	Alltid
Aspiration	Alltid

Abnormality of the breast

Trait	Hvor ofte den forekommer
Wide-spaced nipples	Noen ganger (5–29 %)

Abnormality of the genitourinary system

Trait	Hvor ofte den forekommer
Duplicated collecting system	Noen ganger (5–29 %)

Laboratory abnormality

Trait	Hvor ofte den forekommer
High urine protein levels	Alltid

Hvor ofte dette forekommer hos personer med en av genets tilstander, oppgitt som den hyppigste forekomsten blant dem, slik Human Phenotype Ontology registrerer den. Disse sidene beskriver egenskaper og forskningen bak dem. De er ikke en diagnose, og om symptomer bør du spørre lege eller genetisk rådgiver.

Slik er informasjonen samlet

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WSB2 and how often each is seen. Find out more at hpo.jax.org.

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