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Trait

Palmar hyperkeratosis

Abnormal thickening of the skin localized to the palm of the hand.

HPO HP:0010765

Summary

Body system
Abnormality of limbsAbnormality of the integument

12 genes linked to Palmar hyperkeratosis

Changes in these genes cause rare conditions in which Palmar hyperkeratosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
KRT1keratin 1Often (30–79%)In 1 condition
KRT14keratin 14Often (30–79%)In 3 conditions
KRT16keratin 16Often (30–79%)In 2 conditions
KRT17keratin 17Often (30–79%)In 1 condition
KRT5keratin 5Often (30–79%)In 3 conditions
KRT6Akeratin 6AOften (30–79%)In 2 conditions
KRT6Bkeratin 6BOften (30–79%)In 1 condition
KRT9keratin 9Often (30–79%)In 2 conditions
WNT10AWnt family member 10ASometimes (5–29%)In 1 condition
NECTIN4nectin cell adhesion molecule 4Not recordedIn 1 condition
SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1Not recordedIn 1 condition
ZC4H2zinc finger C4H2-type containingNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal skin morphology of the palmHyperkeratosis

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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