Trait

Excessive sweating of palms and soles

Clinical name: Palmoplantar hyperhidrosis

An abnormally increased perspiration on palms and soles.

HPO HP:0007410

Also called: Hyperhidrosis of palms and soles
Body system: Abnormality of limbs Abnormality of the integument

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14 genes linked to Excessive sweating of palms and soles

Changes in these genes cause rare conditions in which Excessive sweating of palms and soles is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
MBTPS2membrane bound transcription factor peptidase, site 2	Very often (80–99%)	In 1 condition
PERPp53 apoptosis effector related to PMP22	Very often (80–99%)	In 1 condition
PLAAphospholipase A2 activating protein	Very often (80–99%)	In 1 condition
SERPINB7serpin family B member 7	Very often (80–99%)	In 1 condition
TRPV3transient receptor potential cation channel subfamily V member 3	Very often (80–99%)	In 1 condition
CDSNcorneodesmosin	Often (30–79%)	In 1 condition
CFTRCF transmembrane conductance regulator	Often (30–79%)	In 1 condition
KRT16keratin 16	Often (30–79%)	In 1 condition
KRT17keratin 17	Often (30–79%)	In 2 conditions
KRT6Akeratin 6A	Often (30–79%)	In 1 condition
KRT6Bkeratin 6B	Often (30–79%)	In 2 conditions
WNT10AWnt family member 10A	Often (30–79%)	In 2 conditions
CTSBcathepsin B	Not recorded	In 1 condition
RSPO1R-spondin 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the plantar skin of foot Excessive sweating of hands

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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