Trait
Severe farsightedness
Clinical name: High hypermetropia
A severe form of hypermetropia with over +5.00 diopters.
Summary
- Also called
- Severe long-sightedness, High hyperopia, High-grade hypermetropia
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Severe farsightedness, and the rest of your genome, with one test.
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Get my Genome Test73 genes linked to Severe farsightedness
Changes in these genes cause rare conditions in which Severe farsightedness is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARV1ARV1 fatty acid homeostasis modulator | Always | In 1 condition |
| IFT140intraflagellar transport 140 | Always | In 1 condition |
| MFRPmembrane frizzled-related protein | Always | In 3 conditions |
| NMNAT1nicotinamide nucleotide adenylyltransferase 1 | Always | In 1 condition |
| OTX2orthodenticle homeobox 2 | Always | In 2 conditions |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Always | In 1 condition |
| PRSS56serine protease 56 | Always | In 2 conditions |
| SLC6A6solute carrier family 6 member 6 | Always | In 1 condition |
| TOMM7translocase of outer mitochondrial membrane 7 | Always | In 1 condition |
| TUBB4Btubulin beta 4B class IVb | Always | In 1 condition |
| ALDH1A3aldehyde dehydrogenase 1 family member A3 | Very often (80–99%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Very often (80–99%) | In 1 condition |
| BEST1bestrophin 1 | Very often (80–99%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Very often (80–99%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Very often (80–99%) | In 1 condition |
| CRB1crumbs cell polarity complex component 1 | Very often (80–99%) | In 3 conditions |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Very often (80–99%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Very often (80–99%) | In 1 condition |
| ELNelastin | Very often (80–99%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Very often (80–99%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Very often (80–99%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Very often (80–99%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Very often (80–99%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Very often (80–99%) | In 1 condition |
| METTL27methyltransferase like 27 | Very often (80–99%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Very often (80–99%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Very often (80–99%) | In 1 condition |
| RAXretina and anterior neural fold homeobox | Very often (80–99%) | In 1 condition |
| RFC2replication factor C subunit 2 | Very often (80–99%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Very often (80–99%) | In 1 condition |
| SIX6SIX homeobox 6 | Very often (80–99%) | In 1 condition |
| SOX2SRY-box transcription factor 2 | Very often (80–99%) | In 1 condition |
| STX1Asyntaxin 1A | Very often (80–99%) | In 1 condition |
| TBL2transducin beta like 2 | Very often (80–99%) | In 1 condition |
| TMEM270transmembrane protein 270 | Very often (80–99%) | In 1 condition |
| TMEM98transmembrane protein 98 | Very often (80–99%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Very often (80–99%) | In 1 condition |
| AHRaryl hydrocarbon receptor | Often (30–79%) | In 1 condition |
| CASZ1castor zinc finger 1 | Often (30–79%) | In 1 condition |
| CNNM4cyclin and CBS domain divalent metal cation transport mediator 4 | Often (30–79%) | In 1 condition |
Show 33 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CSTAcystatin A | Often (30–79%) | In 1 condition |
| GABRDgamma-aminobutyric acid type A receptor subunit delta | Often (30–79%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Often (30–79%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Often (30–79%) | In 1 condition |
| KCNAB2potassium voltage-gated channel subfamily A regulatory beta subunit 2 | Often (30–79%) | In 1 condition |
| LRMDAleucine rich melanocyte differentiation associated | Often (30–79%) | In 1 condition |
| LUZP1leucine zipper protein 1 | Often (30–79%) | In 1 condition |
| MMP23Bmatrix metallopeptidase 23B | Often (30–79%) | In 1 condition |
| OGTO-linked N-acetylglucosamine (GlcNAc) transferase | Often (30–79%) | In 1 condition |
| PDPNpodoplanin | Often (30–79%) | In 1 condition |
| PRDM16PR/SET domain 16 | Often (30–79%) | In 1 condition |
| PRKCZprotein kinase C zeta | Often (30–79%) | In 1 condition |
| RAI1retinoic acid induced 1 | Often (30–79%) | In 1 condition |
| REREarginine-glutamic acid dipeptide repeats | Often (30–79%) | In 1 condition |
| SKISKI proto-oncogene | Often (30–79%) | In 1 condition |
| SMAD4SMAD family member 4 | Often (30–79%) | In 1 condition |
| SPENspen family transcriptional repressor | Often (30–79%) | In 1 condition |
| TGM5transglutaminase 5 | Often (30–79%) | In 1 condition |
| UBE4Bubiquitination factor E4B | Often (30–79%) | In 1 condition |
| BLOC1S3biogenesis of lysosomal organelles complex 1 subunit 3 | Sometimes (5–29%) | In 1 condition |
| FGF3fibroblast growth factor 3 | Sometimes (5–29%) | In 1 condition |
| FZD5frizzled class receptor 5 | Sometimes (5–29%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| IFT122intraflagellar transport 122 | Sometimes (5–29%) | In 1 condition |
| IFT43intraflagellar transport 43 | Sometimes (5–29%) | In 1 condition |
| IFT52intraflagellar transport 52 | Sometimes (5–29%) | In 1 condition |
| MED25mediator complex subunit 25 | Sometimes (5–29%) | In 2 conditions |
| TAOK1TAO kinase 1 | Sometimes (5–29%) | In 1 condition |
| WDR19WD repeat domain 19 | Sometimes (5–29%) | In 1 condition |
| WDR35WD repeat domain 35 | Sometimes (5–29%) | In 1 condition |
| ZMYM2zinc finger MYM-type containing 2 | Sometimes (5–29%) | In 1 condition |
| LCA5lebercilin LCA5 | Not recorded | In 1 condition |
| RPGRIP1RPGR interacting protein 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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