Trait
Sick sinus syndrome
An abnormality involving the generation of the action potential by the sinus node and is characterized by an atrial rate inappropriate for physiological requirements. Manifestations include severe sinus bradycardia, sinus pauses or arrest, sinus node exit block, chronic atrial tachyarrhythmias, alternating periods of atrial bradyarrhythmias and tachyarrhythmias, and inappropriate responses of heart rate during exercise or stress.
Summary
- Also called
- Sinoatrial node disease
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
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Get my Genome Test31 genes linked to Sick sinus syndrome
Changes in these genes cause rare conditions in which Sick sinus syndrome is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| EMDemerin | Always | In 1 condition |
| GNB5G protein subunit beta 5 | Always | In 3 conditions |
| HCN4hyperpolarization activated cyclic nucleotide gated potassium channel 4 | Always | In 2 conditions |
| NKX2-5NK2 homeobox 5 | Always | In 1 condition |
| SGO1shugoshin 1 | Always | In 1 condition |
| NPPAnatriuretic peptide A | Often (30–79%) | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Often (30–79%) | In 3 conditions |
| ABCC9ATP binding cassette subfamily C member 9 | Sometimes (5–29%) | In 1 condition |
| AKAP9A-kinase anchoring protein 9 | Sometimes (5–29%) | In 1 condition |
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Sometimes (5–29%) | In 1 condition |
| CACNA2D1calcium voltage-gated channel auxiliary subunit alpha2delta 1 | Sometimes (5–29%) | In 1 condition |
| CACNB2calcium voltage-gated channel auxiliary subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| CASQ2calsequestrin 2 | Sometimes (5–29%) | In 1 condition |
| GPD1Lglycerol-3-phosphate dehydrogenase 1 like | Sometimes (5–29%) | In 1 condition |
| KCND3potassium voltage-gated channel subfamily D member 3 | Sometimes (5–29%) | In 1 condition |
| KCNE3potassium voltage-gated channel subfamily E regulatory subunit 3 | Sometimes (5–29%) | In 1 condition |
| KCNE5potassium voltage-gated channel subfamily E regulatory subunit 5 | Sometimes (5–29%) | In 1 condition |
| KCNJ8potassium inwardly rectifying channel subfamily J member 8 | Sometimes (5–29%) | In 1 condition |
| PKP2plakophilin 2 | Sometimes (5–29%) | In 1 condition |
| RANGRFRAN guanine nucleotide release factor | Sometimes (5–29%) | In 1 condition |
| RYR2ryanodine receptor 2 | Sometimes (5–29%) | In 1 condition |
| SCN10Asodium voltage-gated channel alpha subunit 10 | Sometimes (5–29%) | In 1 condition |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Sometimes (5–29%) | In 1 condition |
| SCN2Bsodium voltage-gated channel beta subunit 2 | Sometimes (5–29%) | In 1 condition |
| SCN3Bsodium voltage-gated channel beta subunit 3 | Sometimes (5–29%) | In 1 condition |
| SCNN1Asodium channel epithelial 1 subunit alpha | Sometimes (5–29%) | In 1 condition |
| SEMA3Asemaphorin 3A | Sometimes (5–29%) | In 1 condition |
| SLMAPsarcolemma associated protein | Sometimes (5–29%) | In 1 condition |
| TRDNtriadin | Sometimes (5–29%) | In 1 condition |
| TRPM4transient receptor potential cation channel subfamily M member 4 | Sometimes (5–29%) | In 1 condition |
| MYH6myosin heavy chain 6 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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