Trait
Limited knee straightening
Clinical name: Limited knee extension
Reduced ability to extend (straighten) the knee joint.
Summary
Read the genes linked to Limited knee straightening, and the rest of your genome, with one test.
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Get my Genome Test26 genes linked to Limited knee straightening
Changes in these genes cause rare conditions in which Limited knee straightening is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| SLC13A1solute carrier family 13 member 1 | Always | In 1 condition |
| FBN2fibrillin 2 | Very often (80–99%) | In 1 condition |
| COL9A3collagen type IX alpha 3 chain | Often (30–79%) | In 1 condition |
| CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1 | Often (30–79%) | In 1 condition |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Often (30–79%) | In 1 condition |
| GTPBP1GTP binding protein 1 | Often (30–79%) | In 1 condition |
| GTPBP2GTP binding protein 2 | Often (30–79%) | In 1 condition |
| DPYSL5dihydropyrimidinase like 5 | Sometimes (5–29%) | In 1 condition |
| DYMdymeclin | Sometimes (5–29%) | In 1 condition |
| GABRA1gamma-aminobutyric acid type A receptor subunit alpha1 | Sometimes (5–29%) | In 1 condition |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Sometimes (5–29%) | In 2 conditions |
| PCDH19protocadherin 19 | Sometimes (5–29%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Sometimes (5–29%) | In 2 conditions |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Sometimes (5–29%) | In 2 conditions |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Sometimes (5–29%) | In 2 conditions |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Sometimes (5–29%) | In 2 conditions |
| ADGRV1adhesion G protein-coupled receptor V1 | Rarely (1–4%) | In 1 condition |
| CPA6carboxypeptidase A6 | Rarely (1–4%) | In 1 condition |
| FGF13fibroblast growth factor 13 | Rarely (1–4%) | In 1 condition |
| GABRDgamma-aminobutyric acid type A receptor subunit delta | Rarely (1–4%) | In 1 condition |
| HCN1hyperpolarization activated cyclic nucleotide gated potassium channel 1 | Rarely (1–4%) | In 1 condition |
| PRRT2proline rich transmembrane protein 2 | Rarely (1–4%) | In 1 condition |
| SLC32A1solute carrier family 32 member 1 | Rarely (1–4%) | In 1 condition |
| STX1Bsyntaxin 1B | Rarely (1–4%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Not recorded | In 1 condition |
| GPC6glypican 6 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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