Skip to content
Use your HSA or FSA funds

Gene

SERPIND1

serpin family D member 1

Summary

Cytogenetic location
22q11.21
Coordinates
Chromosome 22: 20,774,113–20,787,720 (GRCh38)
Exons
5 exons across 13.6 kb
Protein
499 amino acids
Also known as
HC-II, HLS2, HC2, D22S673
Previous symbols
HCF2
MANE Select transcript
ENST00000215727.10NM_000185.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Thrombophilia

    • Inherited Thrombophilia
      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Anticoagulation (duration by genotype); avoid estrogen-containing contraceptives; LMWH for pregnancy prophylaxis; extended post-surgical anticoagulation; lifelong anticoagulation for compound/high-risk genotypes

How SERPIND1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 22, with a bracket where SERPIND1 sits. SERPIND1 and 18 genes near it on chromosome 22, from 20,280,917 to 21,280,916.Chromosome 2222q11.21p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3320.4 Mb20.6 Mb20.8 Mb21 Mb21.2 MbRTN4R: 20,241,415–20,283,246, reverse strandRTN4RDGCR6L: 20,312,140–20,320,085, reverse strandDGCR6LZNF74: 20,394,115–20,409,406, forward strandZNF74SCARF2: 20,424,584–20,438,332, reverse strandSCARF2: 20,429,241–20,446,620, reverse strandKLHL22: 20,441,519–20,496,893, reverse strandKLHL22MED15: 20,495,913–20,587,632, forward strandMED15PI4KA: 20,707,691–20,859,417, reverse strandPI4KASERPIND1: 20,774,113–20,787,720, forward strandSERPIND1SNAP29: 20,858,537–20,891,218, forward strandSNAP29CRKL: 20,917,353–20,953,747, forward strandCRKLAIFM3: 20,965,108–20,981,364, forward strandAIFM3LZTR1: 20,981,979–20,999,037, forward strandLZTR1THAP7: 20,999,104–21,002,196, reverse strandTHAP7LRRC74BNL: 21,007,199–21,014,301, reverse strandLRRC74BNL: 21,008,247–21,032,572, reverse strandP2RX6: 21,009,808–21,028,013, forward strandSLC7A4: 21,028,715–21,032,933, reverse strandLRRC74B: 21,045,941–21,064,168, forward strandDiagram of SERPIND1: 5 exons on the forward strand of chromosome 22Exon 1: 20,774,113–20,774,145, 33 basesExon 2: 20,779,297–20,780,201, 905 basesExon 3: 20,783,972–20,784,245, 274 basesExon 4: 20,786,004–20,786,148, 145 basesExon 5: 20,786,875–20,787,720, 846 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 13.6 kb; 1,500 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SERPIND1 gene: serpin family D member 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/serpind1

Vancouver

Dante Labs. SERPIND1 gene: serpin family D member 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/serpind1

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test