Trait
Low sperm count
Clinical name: Oligozoospermia
Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen.
Summary
- Also called
- Oligospermia
- Body system
- Abnormality of the genitourinary system
Reference genomeGRCh38hg38
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Get my Genome Test61 genes linked to Low sperm count
Changes in these genes cause rare conditions in which Low sperm count is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CATSPER1cation channel sperm associated 1 | Always | In 1 condition |
| CATSPER2cation channel sperm associated 2 | Always | In 1 condition |
| CCDC34coiled-coil domain containing 34 | Always | In 1 condition |
| CEP19centrosomal protein 19 | Always | In 1 condition |
| CFAP47cilia and flagella associated protein 47 | Always | In 1 condition |
| CFAP54cilia and flagella associated protein 54 | Always | In 1 condition |
| CFAP65cilia and flagella associated protein 65 | Always | In 1 condition |
| CFAP70cilia and flagella associated protein 70 | Always | In 1 condition |
| CYLC1cylicin 1 | Always | In 1 condition |
| DRC1dynein regulatory complex subunit 1 | Always | In 1 condition |
| DZIP1DAZ interacting zinc finger protein 1 | Always | In 1 condition |
| FBXO43F-box protein 43 | Always | In 1 condition |
| KCNU1potassium calcium-activated channel subfamily U member 1 | Always | In 1 condition |
| KLHL10kelch like family member 10 | Always | In 1 condition |
| M1APmeiosis 1 associated protein | Always | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Always | In 2 conditions |
| RPL10Lribosomal protein L10 like | Always | In 1 condition |
| STRCstereocilin | Always | In 1 condition |
| SYCP2synaptonemal complex protein 2 | Always | In 1 condition |
| TEKT3tektin 3 | Always | In 1 condition |
| CFAP61cilia and flagella associated protein 61 | Very often (80–99%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Very often (80–99%) | In 1 condition |
| BRWD1bromodomain and WD repeat domain containing 1 | Often (30–79%) | In 1 condition |
| CATIPciliogenesis associated TTC17 interacting protein | Often (30–79%) | In 1 condition |
| CFAP20cilia and flagella associated protein 20 | Often (30–79%) | In 1 condition |
| CFAP91cilia and flagella associated protein 91 | Often (30–79%) | In 1 condition |
| DAZ1deleted in azoospermia 1 | Often (30–79%) | In 1 condition |
| DAZ2deleted in azoospermia 2 | Often (30–79%) | In 1 condition |
| DAZ3deleted in azoospermia 3 | Often (30–79%) | In 1 condition |
| DAZ4deleted in azoospermia 4 | Often (30–79%) | In 1 condition |
| DDX3YDEAD-box helicase 3 Y-linked | Often (30–79%) | In 1 condition |
| DNAH10dynein axonemal heavy chain 10 | Often (30–79%) | In 1 condition |
| DNHD1dynein heavy chain domain 1 | Often (30–79%) | In 1 condition |
| FSHBfollicle stimulating hormone subunit beta | Often (30–79%) | In 1 condition |
| IFT74intraflagellar transport 74 | Often (30–79%) | In 1 condition |
| PDHA2pyruvate dehydrogenase E1 subunit alpha 2 | Often (30–79%) | In 1 condition |
| PMFBP1polyamine modulated factor 1 binding protein 1 | Often (30–79%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Often (30–79%) | In 1 condition |
| RBMY1A1RNA binding motif protein Y-linked family 1 member A1 | Often (30–79%) | In 1 condition |
| SEPTIN12septin 12 | Often (30–79%) | In 1 condition |
Show 21 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SUN5Sad1 and UNC84 domain containing 5 | Often (30–79%) | In 1 condition |
| TSPY1testis specific protein Y-linked 1 | Often (30–79%) | In 1 condition |
| USP9Yubiquitin specific peptidase 9 Y-linked | Often (30–79%) | In 1 condition |
| ADGRG2adhesion G protein-coupled receptor G2 | Sometimes (5–29%) | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Sometimes (5–29%) | In 1 condition |
| ANTXR1ANTXR cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| BLMBLM RecQ like helicase | Sometimes (5–29%) | In 1 condition |
| CCINcalicin | Sometimes (5–29%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Sometimes (5–29%) | In 1 condition |
| DNAH12dynein axonemal heavy chain 12 | Sometimes (5–29%) | In 1 condition |
| LHCGRluteinizing hormone/choriogonadotropin receptor | Sometimes (5–29%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Sometimes (5–29%) | In 1 condition |
| PDE11Aphosphodiesterase 11A | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| STK33serine/threonine kinase 33 | Sometimes (5–29%) | In 1 condition |
| ARMC2armadillo repeat containing 2 | Not recorded | In 1 condition |
| CNBPCCHC-type zinc finger nucleic acid binding protein | Not recorded | In 1 condition |
| DNAH17dynein axonemal heavy chain 17 | Not recorded | In 1 condition |
| MSH4mutS homolog 4 | Not recorded | In 1 condition |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Not recorded | In 1 condition |
| POC1APOC1 centriolar protein A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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