Trait

Increased testosterone

Clinical name: Increased serum testosterone level

An elevated circulating testosterone level in the blood.

HPO HP:0030088

Also called: High serum testosterone level, High serum testosterone levels, Increased serum testosterone levels
Body system: Abnormality of the endocrine system

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11 genes linked to Increased testosterone

Changes in these genes cause rare conditions in which Increased testosterone is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CYP11B1cytochrome P450 family 11 subfamily B member 1	Always	In 2 conditions
NR2F2nuclear receptor subfamily 2 group F member 2	Always	In 1 condition
NR3C1nuclear receptor subfamily 3 group C member 1	Always	In 1 condition
ARandrogen receptor	Very often (80–99%)	In 2 conditions
FSHRfollicle stimulating hormone receptor	Very often (80–99%)	In 1 condition
WNT4Wnt family member 4	Very often (80–99%)	In 1 condition
GNASGNAS complex locus	Often (30–79%)	In 1 condition
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Often (30–79%)	In 1 condition
INSRinsulin receptor	Often (30–79%)	In 1 condition
PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha	Often (30–79%)	In 1 condition
POLR3ARNA polymerase III subunit A	Rarely (1–4%)	In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal testosterone level Increased circulating androgen concentration

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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