Trait
Overactive thyroid
Clinical name: Hyperthyroidism
An abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3).
Summary
- Body system
- Abnormality of the endocrine system
Reference genomeGRCh38hg38
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Get my Genome Test36 genes linked to Overactive thyroid
Changes in these genes cause rare conditions in which Overactive thyroid is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Always | In 2 conditions |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Always | In 1 condition |
| GNASGNAS complex locus | Always | In 2 conditions |
| KCNJ18potassium inwardly rectifying channel subfamily J member 18 | Always | In 2 conditions |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| TSHRthyroid stimulating hormone receptor | Always | In 4 conditions |
| CDH23cadherin related 23 | Very often (80–99%) | In 1 condition |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Often (30–79%) | In 1 condition |
| MSTO1misato mitochondrial distribution and morphology regulator 1 | Often (30–79%) | In 2 conditions |
| OSBPL2oxysterol binding protein like 2 | Often (30–79%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Sometimes (5–29%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Sometimes (5–29%) | In 1 condition |
| HIRAhistone cell cycle regulator | Sometimes (5–29%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Sometimes (5–29%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Sometimes (5–29%) | In 1 condition |
| SUGCTsuccinyl-CoA:glutarate-CoA transferase | Sometimes (5–29%) | In 1 condition |
| TBX1T-box transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Sometimes (5–29%) | In 1 condition |
| BTNL2butyrophilin like 2 | Rarely (1–4%) | In 1 condition |
| FOXP3forkhead box P3 | Rarely (1–4%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Rarely (1–4%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Rarely (1–4%) | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Rarely (1–4%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Rarely (1–4%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Rarely (1–4%) | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Rarely (1–4%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Rarely (1–4%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Rarely (1–4%) | In 1 condition |
| DICER1dicer 1, ribonuclease III | Not recorded | In 1 condition |
| KEAP1kelch like ECH associated protein 1 | Not recorded | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Not recorded | In 1 condition |
| PTENphosphatase and tensin homolog | Not recorded | In 1 condition |
| THRBthyroid hormone receptor beta | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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