Trait
Varicose veins
Enlarged and tortuous veins.
Summary
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
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Get my Genome Test31 genes linked to Varicose veins
Changes in these genes cause rare conditions in which Varicose veins is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AEBP1AE binding protein 1 | Always | In 2 conditions |
| COL3A1collagen type III alpha 1 chain | Always | In 3 conditions |
| FIBPFGF1 intracellular binding protein | Always | In 2 conditions |
| NOTCH3notch receptor 3 | Always | In 2 conditions |
| C1Rcomplement C1r | Often (30–79%) | In 1 condition |
| C1Scomplement C1s | Often (30–79%) | In 1 condition |
| EPHB4EPH receptor B4 | Often (30–79%) | In 2 conditions |
| FLT4fms related receptor tyrosine kinase 4 | Often (30–79%) | In 1 condition |
| FOXC2forkhead box C2 | Often (30–79%) | In 2 conditions |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 2 conditions |
| RASA1RAS p21 protein activator 1 | Often (30–79%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Often (30–79%) | In 2 conditions |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| SMAD3SMAD family member 3 | Often (30–79%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Sometimes (5–29%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Sometimes (5–29%) | In 1 condition |
| GJC2gap junction protein gamma 2 | Sometimes (5–29%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Sometimes (5–29%) | In 1 condition |
| HIRAhistone cell cycle regulator | Sometimes (5–29%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Sometimes (5–29%) | In 1 condition |
| KIF5Akinesin family member 5A | Sometimes (5–29%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Sometimes (5–29%) | In 1 condition |
| TBX1T-box transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Sometimes (5–29%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Sometimes (5–29%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 1 condition |
| G6PC3glucose-6-phosphatase catalytic subunit 3 | Not recorded | In 1 condition |
| PIEZO1piezo type mechanosensitive ion channel component 1 (Er blood group) | Not recorded | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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