Trait
Truncus arteriosus
A single arterial trunk arises from the cardiac mass. The pulmonary arteries, aorta and coronary arteries arise from this single trunk with no evidence of another outflow tract.
Summary
- Also called
- Common arterial trunk
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test27 genes linked to Truncus arteriosus
Changes in these genes cause rare conditions in which Truncus arteriosus is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PLXND1plexin D1 | Always | In 2 conditions |
| SMAD2SMAD family member 2 | Always | In 1 condition |
| ARVCFARVCF delta catenin family member | Very often (80–99%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Very often (80–99%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Very often (80–99%) | In 1 condition |
| HIRAhistone cell cycle regulator | Very often (80–99%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Very often (80–99%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Very often (80–99%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Very often (80–99%) | In 1 condition |
| TBX1T-box transcription factor 1 | Very often (80–99%) | In 3 conditions |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Very often (80–99%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Often (30–79%) | In 1 condition |
| CRKLCRK like proto-oncogene, adaptor protein | Often (30–79%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Often (30–79%) | In 1 condition |
| NEK8NIMA related kinase 8 | Often (30–79%) | In 1 condition |
| TMEM260transmembrane protein 260 | Often (30–79%) | In 1 condition |
| GATA6GATA binding protein 6 | Sometimes (5–29%) | In 2 conditions |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Sometimes (5–29%) | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Sometimes (5–29%) | In 1 condition |
| PUF60poly(U) binding splicing factor 60 | Sometimes (5–29%) | In 3 conditions |
| RAB34RAB34, member RAS oncogene family | Sometimes (5–29%) | In 1 condition |
| STRA6signaling receptor and transporter of retinol STRA6 | Sometimes (5–29%) | In 1 condition |
| DLL4delta like canonical Notch ligand 4 | Rarely (1–4%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Rarely (1–4%) | In 1 condition |
| GJA8gap junction protein alpha 8 | Rarely (1–4%) | In 1 condition |
| NKX2-5NK2 homeobox 5 | Not recorded | In 1 condition |
| NKX2-6NK2 homeobox 6 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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