Trait
Interruption of electrical communication between upper and lower chambers of heart
Clinical name: Atrioventricular block
Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles.
Summary
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Interruption of electrical communication between upper and lower chambers of heart, and the rest of your genome, with one test.
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Get my Genome Test41 genes linked to Interruption of electrical communication between upper and lower chambers of heart
Changes in these genes cause rare conditions in which Interruption of electrical communication between upper and lower chambers of heart is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| NKX2-5NK2 homeobox 5 | Always | In 1 condition |
| CACNA1Ccalcium voltage-gated channel subunit alpha1 C | Very often (80–99%) | In 1 condition |
| GNB2G protein subunit beta 2 | Very often (80–99%) | In 1 condition |
| GPX4glutathione peroxidase 4 | Very often (80–99%) | In 1 condition |
| DESdesmin | Often (30–79%) | In 1 condition |
| GLAgalactosidase alpha | Often (30–79%) | In 1 condition |
| LAMP2lysosome associated membrane protein 2 | Often (30–79%) | In 1 condition |
| LMNAlamin A/C | Often (30–79%) | In 3 conditions |
| TBX5T-box transcription factor 5 | Often (30–79%) | In 1 condition |
| TTRtransthyretin | Often (30–79%) | In 1 condition |
| ACTN2actinin alpha 2 | Sometimes (5–29%) | In 1 condition |
| CACNA2D1calcium voltage-gated channel auxiliary subunit alpha2delta 1 | Sometimes (5–29%) | In 1 condition |
| CAPNS1calpain small subunit 1 | Sometimes (5–29%) | In 1 condition |
| CASQ2calsequestrin 2 | Sometimes (5–29%) | In 1 condition |
| EMDemerin | Sometimes (5–29%) | In 2 conditions |
| FHL1four and a half LIM domains 1 | Sometimes (5–29%) | In 1 condition |
| FLNCfilamin C | Sometimes (5–29%) | In 1 condition |
| KCNH2potassium voltage-gated channel subfamily H member 2 | Sometimes (5–29%) | In 1 condition |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Sometimes (5–29%) | In 1 condition |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Sometimes (5–29%) | In 1 condition |
| KCNQ1potassium voltage-gated channel subfamily Q member 1 | Sometimes (5–29%) | In 1 condition |
| MMP14matrix metallopeptidase 14 | Sometimes (5–29%) | In 1 condition |
| MMP2matrix metallopeptidase 2 | Sometimes (5–29%) | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Sometimes (5–29%) | In 1 condition |
| PRKAG2protein kinase AMP-activated non-catalytic subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| RYR2ryanodine receptor 2 | Sometimes (5–29%) | In 1 condition |
| SLC4A3solute carrier family 4 member 3 | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| SYNE2spectrin repeat containing nuclear envelope protein 2 | Sometimes (5–29%) | In 1 condition |
| TFR2transferrin receptor 2 | Sometimes (5–29%) | In 1 condition |
| TLL1tolloid like 1 | Sometimes (5–29%) | In 1 condition |
| TMEM43transmembrane protein 43 | Sometimes (5–29%) | In 1 condition |
| TRDNtriadin | Sometimes (5–29%) | In 1 condition |
| TTNtitin | Sometimes (5–29%) | In 2 conditions |
| ACADVLacyl-CoA dehydrogenase very long chain | Rarely (1–4%) | In 1 condition |
| AGXTalanine--glyoxylate aminotransferase | Not recorded | In 1 condition |
| MYBPC3myosin binding protein C3 | Not recorded | In 1 condition |
| SCN4Bsodium voltage-gated channel beta subunit 4 | Not recorded | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Not recorded | In 2 conditions |
| SLC25A20solute carrier family 25 member 20 | Not recorded | In 1 condition |
Show 1 more gene
| Gene | How often it is seen | Conditions |
|---|---|---|
| TRPM4transient receptor potential cation channel subfamily M member 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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