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Gene

CDK19

cyclin dependent kinase 19

Summary

Cytogenetic location
6q21
Coordinates
Chromosome 6: 110,609,978–110,815,469 (GRCh38)
Exons
13 exons across 205.5 kb
Protein
502 amino acids
Also known as
KIAA1028, bA346C16.3
Previous symbols
CDK11, CDC2L6
MANE Select transcript
ENST00000368911.8NM_015076.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 2 GenCC submitters rate it definitive or strong

    How CDK19 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 6, with a bracket where CDK19 sits. CDK19 and 8 genes near it on chromosome 6, from 110,212,724 to 111,212,723.Chromosome 66q21p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27110.4 Mb110.6 Mb110.8 Mb111 Mb111.2 MbCDC40: 110,180,141–110,254,275, forward strandCDC40METTL24: 110,242,892–110,358,502, reverse strandMETTL24DDO: 110,388,321–110,415,862, reverse strandDDOSLC22A16: 110,424,687–110,476,681, reverse strandSLC22A16CDK19: 110,609,978–110,815,469, reverse strandCDK19AMD1: 110,874,770–110,898,879, forward strandAMD1GTF3C6: 110,958,477–110,968,586, forward strandGTF3C6RPF2: 110,982,015–111,028,264, forward strandRPF2SLC16A10: 111,087,445–111,258,090, forward strandSLC16A10Diagram of CDK19: 13 exons on the reverse strand of chromosome 6Exon 6: 1 known disease-causing siteExon 1: 3 known disease-causing sitesExon 13: 110,609,978–110,614,666, 4,689 basesExon 12: 110,621,104–110,621,370, 267 basesExon 11: 110,622,088–110,622,166, 79 basesExon 10: 110,622,815–110,622,912, 98 basesExon 9: 110,623,290–110,623,362, 73 basesExon 8: 110,626,776–110,626,845, 70 basesExon 7: 110,627,002–110,627,145, 144 basesExon 6: 110,632,030–110,632,161, 132 basesExon 5: 110,638,649–110,638,706, 58 basesExon 4: 110,667,434–110,667,574, 141 basesExon 3: 110,670,431–110,670,541, 111 basesExon 2: 110,746,126–110,746,201, 76 basesExon 1: 110,815,009–110,815,469, 461 bases1310515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 6.4 kb of the gene's 205.5 kb; 1,509 of those bases code for the protein.

    How a genome test reads CDK19

    4

    positions in CDK19 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 205.5 kb of CDK19, introns included, not only the 6.4 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). CDK19 gene: cyclin dependent kinase 19. Retrieved 16 October 2026, from https://dantelabs.com/genes/cdk19

    Vancouver

    Dante Labs. CDK19 gene: cyclin dependent kinase 19 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cdk19

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