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Gene

DYNC1I2

dynein cytoplasmic 1 intermediate chain 2

Summary

Cytogenetic location
2q31.1
Coordinates
Chromosome 2: 171,687,469–171,750,158 (GRCh38)
Exons
18 exons across 62.7 kb
Protein
638 amino acids
Also known as
DIC74
Previous symbols
DNCI2
MANE Select transcript
ENST00000397119.8NM_001378.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads DYNC1I2 yet. The test sequences your whole genome, so your data includes it all the same.

How DYNC1I2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where DYNC1I2 sits. DYNC1I2 and 9 genes near it on chromosome 2, from 171,218,814 to 172,218,813.Chromosome 22q31.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3171.4 Mb171.6 Mb171.8 Mb172 Mb172.2 MbTLK1: 170,990,823–171,231,314, reverse strandTLK1METTL8: 171,315,746–171,434,802, reverse strandMETTL8DCAF17: 171,434,217–171,491,318, forward strandDCAF17CYBRD1: 171,522,247–171,558,133, forward strandCYBRD1DYNC1I2: 171,687,469–171,750,158, forward strandDYNC1I2SLC25A12: 171,781,168–171,999,859, reverse strandSLC25A12HAT1: 171,922,404–171,986,773, forward strandHAT1METAP1D: 171,999,935–172,083,989, forward strandMETAP1DDLX1: 172,084,469–172,089,677, forward strandDLX1DLX2: 172,099,438–172,102,909, reverse strandDLX2Diagram of DYNC1I2: 18 exons on the forward strand of chromosome 2Exon 9: 1 known disease-causing siteExon 1: 171,687,469–171,687,627, 159 basesExon 2: 171,690,147–171,690,263, 117 basesExon 3: 171,692,777–171,692,894, 118 basesExon 4: 171,706,547–171,706,564, 18 basesExon 5: 171,707,287–171,707,377, 91 basesExon 6: 171,712,767–171,712,826, 60 basesExon 7: 171,715,328–171,715,443, 116 basesExon 8: 171,725,618–171,725,713, 96 basesExon 9: 171,725,919–171,726,081, 163 basesExon 10: 171,726,194–171,726,293, 100 basesExon 11: 171,726,791–171,726,916, 126 basesExon 12: 171,727,821–171,727,967, 147 basesExon 13: 171,728,305–171,728,418, 114 basesExon 14: 171,728,717–171,728,850, 134 basesExon 15: 171,729,709–171,729,853, 145 basesExon 16: 171,744,049–171,744,189, 141 basesExon 17: 171,745,802–171,745,927, 126 basesExon 18: 171,747,776–171,750,158, 2,383 bases151015185′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 62.7 kb; 1,917 of those bases code for the protein.

How a genome test reads DYNC1I2

2

positions in DYNC1I2 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (50%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

A whole genome covers all 62.7 kb of DYNC1I2, introns included, not only the 4.4 kb of exons.

Traits linked to DYNC1I2

The Human Phenotype Ontology lists these as features of the rare conditions DYNC1I2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DYNC1I2 gene: dynein cytoplasmic 1 intermediate chain 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/dync1i2

Vancouver

Dante Labs. DYNC1I2 gene: dynein cytoplasmic 1 intermediate chain 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dync1i2

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