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Gene

PRUNE1

prune exopolyphosphatase 1

Summary

Cytogenetic location
1q21.3
Coordinates
Chromosome 1: 151,008,449–151,035,713 (GRCh38)
Exons
8 exons across 27.3 kb
Protein
453 amino acids
Also known as
DRES-17, HTCD37, H-PRUNE
Previous symbols
PRUNE
MANE Select transcript
ENST00000271620.8NM_021222.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PRUNE1 yet. The test sequences your whole genome, so your data includes it all the same.

How PRUNE1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where PRUNE1 sits. PRUNE1 and 33 genes near it on chromosome 1, from 150,522,081 to 151,522,080.Chromosome 11q21.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44150.6 Mb150.8 Mb151 Mb151.2 Mb151.4 MbADAMTSL4: 150,549,369–150,560,937, forward strandADAMTSL4MCL1: 150,560,895–150,579,738, reverse strandMCL1ENSA: 150,599,671–150,629,633, reverse strandENSAGOLPH3L: 150,638,727–150,697,222, reverse strandGOLPH3LHORMAD1: 150,698,059–150,720,895, reverse strandHORMAD1CTSS: 150,730,079–150,765,957, reverse strandCTSSCTSK: 150,794,880–150,809,577, reverse strandCTSKARNT: 150,808,617–150,876,771, reverse strandARNTCTXND2: 150,887,136–150,913,292, forward strandCTXND2SETDB1: 150,926,263–150,964,748, forward strandSETDB1CERS2: 150,959,099–150,977,396, reverse strandCERS2ANXA9: 150,981,321–150,996,077, forward strandANXA9MINDY1: 150,995,125–151,008,376, reverse strandMINDY1PRUNE1: 151,008,449–151,035,713, forward strandPRUNE1BNIPL: 151,036,321–151,047,720, forward strandBNIPLC1orf56: 151,047,746–151,051,986, forward strandC1orf56CDC42SE1: 151,050,242–151,070,325, reverse strandMLLT11: 151,054,177–151,069,544, forward strandGABPB2: 151,070,514–151,130,109, forward strandSEMA6C: 151,131,685–151,147,813, reverse strandSEMA6CTIPE2: 151,156,621–151,160,255, forward strandTIPE2SCNM1: 151,156,664–151,179,006, forward strandSCNM1LYSMD1: 151,159,748–151,165,948, reverse strandLYSMD1TMOD4: 151,169,984–151,176,284, reverse strandVPS72: 151,176,304–151,195,321, reverse strandPIP5K1A: 151,197,949–151,249,538, forward strandPIP5K1APSMD4: 151,254,709–151,279,502, forward strandPSMD4ZNF687: 151,281,502–151,292,180, forward strandZNF687PI4KB: 151,291,792–151,328,394, reverse strandPI4KBRFX5: 151,340,640–151,347,339, reverse strandRFX5SELENBP1: 151,364,157–151,372,716, reverse strandSELENBP1PSMB4: 151,399,556–151,401,941, forward strandPSMB4POGZ: 151,402,724–151,459,511, reverse strandPOGZCGN: 151,510,139–151,538,692, forward strandCGNDiagram of PRUNE1: 8 exons on the forward strand of chromosome 1Exon 2: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 1: 151,008,449–151,008,671, 223 basesExon 2: 151,017,812–151,017,904, 93 basesExon 3: 151,018,467–151,018,669, 203 basesExon 4: 151,024,611–151,024,795, 185 basesExon 5: 151,025,515–151,025,673, 159 basesExon 6: 151,027,233–151,027,327, 95 basesExon 7: 151,028,786–151,028,944, 159 basesExon 8: 151,033,806–151,035,713, 1,908 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3 kb of the gene's 27.3 kb; 1,362 of those bases code for the protein.

How a genome test reads PRUNE1

8

positions in PRUNE1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 27.3 kb of PRUNE1, introns included, not only the 3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PRUNE1 gene: prune exopolyphosphatase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/prune1

Vancouver

Dante Labs. PRUNE1 gene: prune exopolyphosphatase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/prune1

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