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Gene

FCSK

fucose kinase

Summary

Cytogenetic location
16q22.1
Coordinates
Chromosome 16: 70,454,595–70,480,274 (GRCh38)
Exons
24 exons across 25.7 kb
Protein
1,084 amino acids
Also known as
FLJ39408
Previous symbols
FUK
MANE Select transcript
ENST00000288078.11NM_145059.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Congenital Disorders of Glycosylation

      • Congenital Disorders of Glycosylation (CDG)

        One of 98 genes linked to it

        A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

        • 2 GenCC submitters rate it definitive or strong

    How FCSK is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 16, with a bracket where FCSK sits. FCSK and 14 genes near it on chromosome 16, from 69,967,435 to 70,967,434.Chromosome 1616q22.1p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.370 Mb70.2 Mb70.4 Mb70.6 Mb70.8 MbPDPR: 70,114,225–70,162,537, forward strandPDPRCLEC18C: 70,173,322–70,187,361, forward strandCLEC18CEXOSC6: 70,246,778–70,251,940, reverse strandEXOSC6AARS1: 70,251,983–70,289,707, reverse strandAARS1DDX19B: 70,289,663–70,335,992, forward strandDDX19B: 70,299,194–70,372,582, forward strandDDX19A: 70,346,861–70,379,987, forward strandDDX19AST3GAL2: 70,375,977–70,439,263, reverse strandST3GAL2FCSK: 70,454,595–70,480,274, forward strandFCSKCOG4: 70,480,567–70,523,582, reverse strandCOG4SF3B3: 70,523,782–70,577,670, forward strandSF3B3IL34: 70,579,868–70,661,556, forward strandIL34MTSS2: 70,661,204–70,686,086, reverse strandMTSS2VAC14: 70,687,436–70,801,178, reverse strandVAC14HYDIN: 70,802,084–71,230,735, reverse strandHYDINDiagram of FCSK: 24 exons on the forward strand of chromosome 16Exon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 1: 70,454,595–70,454,630, 36 basesExon 2: 70,463,169–70,463,272, 104 basesExon 3: 70,463,623–70,463,774, 152 basesExon 4: 70,465,126–70,465,176, 51 basesExon 5: 70,466,132–70,466,257, 126 basesExon 6: 70,466,882–70,466,954, 73 basesExon 7: 70,467,374–70,467,471, 98 basesExon 8: 70,467,886–70,467,966, 81 basesExon 9: 70,468,849–70,468,968, 120 basesExon 10: 70,469,152–70,469,323, 172 basesExon 11: 70,470,314–70,470,426, 113 basesExon 12: 70,470,971–70,471,072, 102 basesExon 13: 70,471,182–70,471,352, 171 basesExon 14: 70,472,541–70,472,605, 65 basesExon 15: 70,472,983–70,473,353, 371 basesExon 16: 70,474,129–70,474,339, 211 basesExon 17: 70,474,528–70,474,694, 167 basesExon 18: 70,474,790–70,475,011, 222 basesExon 19: 70,475,350–70,475,493, 144 basesExon 20: 70,475,648–70,475,767, 120 basesExon 21: 70,478,272–70,478,459, 188 basesExon 22: 70,478,551–70,478,650, 100 basesExon 23: 70,479,180–70,479,403, 224 basesExon 24: 70,479,579–70,480,274, 696 bases1246810121416182022245′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.9 kb of the gene's 25.7 kb; 3,255 of those bases code for the protein.

    How a genome test reads FCSK

    12

    positions in FCSK where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 25.7 kb of FCSK, introns included, not only the 3.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). FCSK gene: fucose kinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/fcsk

    Vancouver

    Dante Labs. FCSK gene: fucose kinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fcsk

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