Skip to content
Use your HSA or FSA funds

Gene

BRAT1

BRCA1 associated ATM activator 1

Summary

Cytogenetic location
7p22.3
Coordinates
Chromosome 7: 2,537,810–2,555,524 (GRCh38)
Exons
14 exons across 17.7 kb
Protein
821 amino acids
Also known as
MGC22916
Previous symbols
C7orf27, BAAT1
MANE Select transcript
ENST00000340611.9NM_152743.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong

    How BRAT1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 7, with a bracket where BRAT1 sits. BRAT1 and 14 genes near it on chromosome 7, from 2,046,667 to 3,046,666.Chromosome 77p22.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.32.2 Mb2.4 Mb2.6 Mb2.8 Mb3 MbMAD1L1: 1,815,787–2,233,243, reverse strandMAD1L1: 1,815,804–2,242,215, reverse strandMRM2: 2,234,195–2,242,229, reverse strandMRM2NUDT1: 2,242,203–2,251,824, forward strandNUDT1SNX8: 2,251,770–2,354,318, reverse strandSNX8EIF3B: 2,354,080–2,380,747, forward strandEIF3BCHST12: 2,403,442–2,448,484, forward strandCHST12GRIFIN: 2,474,728–2,476,894, reverse strandGRIFINLFNG: 2,512,529–2,529,177, forward strandLFNGBRAT1: 2,537,810–2,555,524, reverse strandBRAT1IQCE: 2,558,903–2,614,733, forward strandIQCETTYH3: 2,631,898–2,664,816, forward strandTTYH3AMZ1: 2,679,276–2,775,500, forward strandAMZ1GNA12: 2,721,820–2,870,786, reverse strandGNA12CARD11: 2,905,881–3,044,228, reverse strandCARD11Diagram of BRAT1: 14 exons on the reverse strand of chromosome 7Exon 14: 16 known disease-causing sitesExon 13: 5 known disease-causing sitesExon 12: 4 known disease-causing sitesExon 11: 9 known disease-causing sitesExon 10: 1 known disease-causing siteExon 9: 6 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 5: 11 known disease-causing sitesExon 4: 6 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 2: 5 known disease-causing sitesExon 14: 2,537,810–2,538,764, 955 basesExon 13: 2,539,179–2,539,351, 173 basesExon 12: 2,539,544–2,539,642, 99 basesExon 11: 2,539,786–2,539,888, 103 basesExon 10: 2,540,979–2,541,052, 74 basesExon 9: 2,541,298–2,541,484, 187 basesExon 8: 2,541,718–2,541,836, 119 basesExon 7: 2,542,120–2,542,211, 92 basesExon 6: 2,543,204–2,543,323, 120 basesExon 5: 2,543,590–2,543,962, 373 basesExon 4: 2,544,909–2,545,056, 148 basesExon 3: 2,547,324–2,547,478, 155 basesExon 2: 2,554,305–2,554,447, 143 basesExon 1: 2,555,487–2,555,524, 38 bases141210864215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.8 kb of the gene's 17.7 kb; 2,466 of those bases code for the protein.

    How a genome test reads BRAT1

    87

    positions in BRAT1 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 17.7 kb of BRAT1, introns included, not only the 2.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). BRAT1 gene: BRCA1 associated ATM activator 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/brat1

    Vancouver

    Dante Labs. BRAT1 gene: BRCA1 associated ATM activator 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/brat1

    One test. A lifetime of answers.

    From $449Free shipping · Results in 6–8 weeks

    Get my Genome Test