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Gene

DYRK1B

dual specificity tyrosine phosphorylation regulated kinase 1B

Summary

Cytogenetic location
19q13.2
Coordinates
Chromosome 19: 39,825,350–39,834,162 (GRCh38)
Exons
11 exons across 8.8 kb
Protein
629 amino acids
Also known as
MIRK
MANE Select transcript
ENST00000323039.10NM_004714.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DYRK1B yet. The test sequences your whole genome, so your data includes it all the same.

How DYRK1B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 19, with a bracket where DYRK1B sits. DYRK1B and 30 genes near it on chromosome 19, from 39,329,756 to 40,329,755.Chromosome 1919q13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4339.4 Mb39.6 Mb39.8 Mb40 Mb40.2 MbGMFG: 39,328,351–39,342,372, reverse strandGMFGSAMD4B: 39,342,404–39,385,710, forward strandPAF1: 39,385,629–39,391,154, reverse strandMED29: 39,391,303–39,400,641, forward strandMED29ZFP36: 39,406,412–39,411,635, forward strandZFP36PLEKHG2: 39,412,546–39,428,415, forward strandPLEKHG2RPS16: 39,433,136–39,436,131, reverse strandRPS16SUPT5H: 39,436,156–39,476,670, forward strandSUPT5HTIMM50: 39,479,795–39,493,785, forward strandDLL3: 39,498,895–39,508,481, forward strandDLL3SELENOV: 39,515,139–39,520,675, forward strandSELENOVEID2B: 39,525,527–39,532,881, reverse strandEID2BEID2: 39,536,438–39,540,233, reverse strandEID2LGALS13: 39,602,490–39,607,476, forward strandLGALS13LGALS16: 39,655,908–39,660,647, forward strandLGALS16LGALS14: 39,704,359–39,727,560, forward strandLGALS14CLC: 39,731,255–39,755,237, reverse strandCLCLEUTX: 39,776,595–39,786,291, forward strandLEUTXDYRK1B: 39,825,350–39,834,162, reverse strandDYRK1B: 39,830,482–39,831,956, reverse strandFBL: 39,834,443–39,846,440, reverse strandFBLFCGBP: 39,863,323–39,934,634, reverse strandFCGBPPSMC4: 39,970,990–39,982,814, forward strandPSMC4ZNF546: 39,984,134–40,021,038, forward strandZNF546ZNF780B: 40,023,079–40,056,305, reverse strandZNF780BZNF780A: 40,069,152–40,091,140, reverse strandZNF780AMAP3K10: 40,191,412–40,215,579, forward strandMAP3K10TTC9B: 40,216,058–40,218,521, reverse strandTTC9BCCNP: 40,222,208–40,226,697, reverse strandCCNPAKT2: 40,230,317–40,285,536, reverse strandAKT2C19orf47: 40,294,427–40,348,547, reverse strandC19orf47Diagram of DYRK1B: 11 exons on the reverse strand of chromosome 19Exon 4: 1 known disease-causing siteExon 11: 39,825,350–39,826,086, 737 basesExon 10: 39,826,180–39,826,286, 107 basesExon 9: 39,826,672–39,826,987, 316 basesExon 8: 39,827,285–39,827,425, 141 basesExon 7: 39,827,510–39,827,656, 147 basesExon 6: 39,828,297–39,828,583, 287 basesExon 5: 39,829,880–39,830,027, 148 basesExon 4: 39,830,375–39,830,563, 189 basesExon 3: 39,830,664–39,830,783, 120 basesExon 2: 39,831,805–39,831,968, 164 basesExon 1: 39,834,023–39,834,162, 140 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 8.8 kb; 1,890 of those bases code for the protein.

How a genome test reads DYRK1B

1

position in DYRK1B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 8.8 kb of DYRK1B, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DYRK1B gene: dual specificity tyrosine phosphorylation regulated kinase 1B. Retrieved 17 October 2026, from https://dantelabs.com/genes/dyrk1b

Vancouver

Dante Labs. DYRK1B gene: dual specificity tyrosine phosphorylation regulated kinase 1B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dyrk1b

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