Trait

Low calcium seizures

Clinical name: Hypocalcemic seizures

HPO HP:0002199

Also called: Seizures due to hypocalcemia
Body system: Abnormality of the nervous system

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12 genes linked to Low calcium seizures

Changes in these genes cause rare conditions in which Low calcium seizures is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
PTHparathyroid hormone	Always	In 1 condition
TBCEtubulin folding cofactor E	Always	In 2 conditions
GCM2GCM transcription factor 2	Very often (80–99%)	In 2 conditions
CLDN16claudin 16	Often (30–79%)	In 1 condition
FAM111AFAM111 trypsin like peptidase A	Often (30–79%)	In 1 condition
GATA3GATA binding protein 3	Often (30–79%)	In 1 condition
CYP27B1cytochrome P450 family 27 subfamily B member 1	Sometimes (5–29%)	In 2 conditions
CYP2R1cytochrome P450 family 2 subfamily R member 1	Sometimes (5–29%)	In 1 condition
TNFRSF11ATNF receptor superfamily member 11a	Sometimes (5–29%)	In 1 condition
GNASGNAS complex locus	Rarely (1–4%)	In 3 conditions
STX16syntaxin 16	Rarely (1–4%)	In 1 condition
VDRvitamin D receptor	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Symptomatic seizures

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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