Trait
High blood uric acid level
Clinical name: Hyperuricemia
The concentration of uric acid in the blood circulation is above the upper limit of normal.
Summary
- Also called
- Elevated uric acid concentration, Elevated uric acid level, Elevated uric acid level in blood, Hyperuricaemia, Increased uric acid concentration, Increased uric acid level, Increased uric acid level in blood
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Get my Genome Test32 genes linked to High blood uric acid level
Changes in these genes cause rare conditions in which High blood uric acid level is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CLDN16claudin 16 | Always | In 1 condition |
| HPRT1hypoxanthine phosphoribosyltransferase 1 | Always | In 4 conditions |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Always | In 3 conditions |
| SARS2seryl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| SEC61A1SEC61 translocon subunit alpha 1 | Always | In 2 conditions |
| SLC17A3solute carrier family 17 member 3 | Always | In 1 condition |
| ACAT1acetyl-CoA acetyltransferase 1 | Very often (80–99%) | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Very often (80–99%) | In 3 conditions |
| TNFRSF11ATNF receptor superfamily member 11a | Very often (80–99%) | In 1 condition |
| TNFRSF11BTNF receptor superfamily member 11b | Very often (80–99%) | In 2 conditions |
| ADRA2Aadrenoceptor alpha 2A | Often (30–79%) | In 1 condition |
| FBP1fructose-bisphosphatase 1 | Often (30–79%) | In 1 condition |
| HMGCL3-hydroxy-3-methylglutaryl-CoA lyase | Often (30–79%) | In 2 conditions |
| HNF1BHNF1 homeobox B | Often (30–79%) | In 2 conditions |
| LMNAlamin A/C | Often (30–79%) | In 1 condition |
| MYCMYC proto-oncogene, bHLH transcription factor | Often (30–79%) | In 1 condition |
| PFKMphosphofructokinase, muscle | Often (30–79%) | In 2 conditions |
| PYGMglycogen phosphorylase, muscle associated | Often (30–79%) | In 1 condition |
| SH2B1SH2B adaptor protein 1 | Often (30–79%) | In 1 condition |
| UMODuromodulin | Often (30–79%) | In 1 condition |
| ALDOBaldolase, fructose-bisphosphate B | Sometimes (5–29%) | In 2 conditions |
| G6PC1glucose-6-phosphatase catalytic subunit 1 | Sometimes (5–29%) | In 1 condition |
| PHKA2phosphorylase kinase regulatory subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PHKBphosphorylase kinase regulatory subunit beta | Sometimes (5–29%) | In 1 condition |
| PPARGperoxisome proliferator activated receptor gamma | Sometimes (5–29%) | In 2 conditions |
| LMAN1lectin, mannose binding 1 | Rarely (1–4%) | In 1 condition |
| MCFD2multiple coagulation factor deficiency 2, ER cargo receptor complex subunit | Rarely (1–4%) | In 1 condition |
| ABCG2ATP binding cassette subfamily G member 2 (JR blood group) | Not recorded | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Not recorded | In 1 condition |
| MUC1mucin 1, cell surface associated | Not recorded | In 1 condition |
| RENrenin | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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