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Gene

LRRK1

leucine rich repeat kinase 1

Summary

Cytogenetic location
15q26.3
Coordinates
Chromosome 15: 100,919,357–101,078,257 (GRCh38)
Exons
34 exons across 158.9 kb
Protein
2,015 amino acids
Also known as
FLJ23119, KIAA1790, ROCO1, RIPK6
MANE Select transcript
ENST00000388948.8NM_024652.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Osteopetrosis

    • Osteopetrosis, also known as marble bone disease, is a descriptive term that refers to a group of rare, heritable disorders of the skeleton characterized by increased bone density on radiographs.

      • 1 GenCC submitter rates it definitive or strong

How LRRK1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where LRRK1 sits. LRRK1 and 8 genes near it on chromosome 15, from 100,498,807 to 101,498,806.Chromosome 1515q26.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.3100.6 Mb100.8 Mb101 Mb101.2 Mb101.4 MbCERS3: 100,400,395–100,544,995, reverse strandCERS3LINS1: 100,559,369–100,603,230, reverse strandLINS1ASB7: 100,602,518–100,651,703, forward strandASB7ALDH1A3: 100,861,924–100,916,760, forward strandALDH1A3LRRK1: 100,919,357–101,078,257, forward strandLRRK1CHSY1: 101,145,640–101,252,339, reverse strandCHSY1SELENOS: 101,270,329–101,277,500, reverse strandSELENOSSNRPA1: 101,281,508–101,295,305, reverse strandSNRPA1PCSK6: 101,289,784–101,525,202, reverse strandPCSK6Diagram of LRRK1: 34 exons on the forward strand of chromosome 15Exon 12: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 28: 1 known disease-causing siteExon 33: 1 known disease-causing siteExon 34: 1 known disease-causing siteExon 1: 100,919,357–100,919,451, 95 basesExon 2: 100,924,511–100,924,729, 219 basesExon 3: 100,973,804–100,973,967, 164 basesExon 4: 100,983,528–100,983,699, 172 basesExon 5: 100,988,634–100,988,813, 180 basesExon 6: 100,989,250–100,989,398, 149 basesExon 7: 101,008,837–101,009,063, 227 basesExon 8: 101,010,450–101,010,577, 128 basesExon 9: 101,010,674–101,010,837, 164 basesExon 10: 101,012,008–101,012,145, 138 basesExon 11: 101,014,316–101,014,428, 113 basesExon 12: 101,015,326–101,015,402, 77 basesExon 13: 101,021,053–101,021,182, 130 basesExon 14: 101,021,845–101,021,957, 113 basesExon 15: 101,022,383–101,022,597, 215 basesExon 16: 101,024,803–101,024,967, 165 basesExon 17: 101,025,965–101,026,137, 173 basesExon 18: 101,027,261–101,027,381, 121 basesExon 19: 101,027,638–101,027,797, 160 basesExon 20: 101,028,956–101,029,232, 277 basesExon 21: 101,045,981–101,046,152, 172 basesExon 22: 101,048,494–101,048,657, 164 basesExon 23: 101,049,644–101,049,783, 140 basesExon 24: 101,051,711–101,051,960, 250 basesExon 25: 101,052,922–101,053,088, 167 basesExon 26: 101,053,223–101,053,420, 198 basesExon 27: 101,054,946–101,055,223, 278 basesExon 28: 101,056,856–101,057,050, 195 basesExon 29: 101,057,990–101,058,141, 152 basesExon 30: 101,061,171–101,061,288, 118 basesExon 31: 101,062,574–101,062,690, 117 basesExon 32: 101,065,352–101,066,205, 854 basesExon 33: 101,066,640–101,066,741, 102 basesExon 34: 101,068,671–101,078,257, 9,587 bases151015202530345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 15.7 kb of the gene's 158.9 kb; 6,048 of those bases code for the protein.

How a genome test reads LRRK1

6

positions in LRRK1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 158.9 kb of LRRK1, introns included, not only the 15.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LRRK1 gene: leucine rich repeat kinase 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/lrrk1

Vancouver

Dante Labs. LRRK1 gene: leucine rich repeat kinase 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lrrk1

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