Trait
Increased urine output
Clinical name: Polyuria
An increased rate of urine production.
Summary
- Body system
- Abnormality of the genitourinary system
Reference genomeGRCh38hg38
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Get my Genome Test39 genes linked to Increased urine output
Changes in these genes cause rare conditions in which Increased urine output is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AQP2aquaporin 2 | Always | In 1 condition |
| AVPR2arginine vasopressin receptor 2 | Always | In 1 condition |
| BBS2Bardet-Biedl syndrome 2 | Always | In 1 condition |
| BSNDbarttin CLCNK type accessory subunit beta | Always | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Always | In 1 condition |
| LZTFL1leucine zipper transcription factor like 1 | Always | In 1 condition |
| NEK8NIMA related kinase 8 | Always | In 2 conditions |
| PAX4paired box 4 | Always | In 1 condition |
| SARS2seryl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| SLC41A1solute carrier family 41 member 1 | Always | In 1 condition |
| SONSON DNA and RNA binding protein | Always | In 1 condition |
| CLDN16claudin 16 | Very often (80–99%) | In 1 condition |
| ATP1A1ATPase Na+/K+ transporting subunit alpha 1 | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Often (30–79%) | In 1 condition |
| CYP24A1cytochrome P450 family 24 subfamily A member 1 | Often (30–79%) | In 1 condition |
| NPHP1nephrocystin 1 | Often (30–79%) | In 2 conditions |
| NPHP3nephrocystin 3 | Often (30–79%) | In 1 condition |
| RRAGDRas related GTP binding D | Often (30–79%) | In 1 condition |
| SLC34A1solute carrier family 34 member 1 | Often (30–79%) | In 1 condition |
| UMODuromodulin | Often (30–79%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Sometimes (5–29%) | In 1 condition |
| CASRcalcium sensing receptor | Not recorded | In 1 condition |
| CLCNKAchloride voltage-gated channel Ka | Not recorded | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Not recorded | In 2 conditions |
| CLDN10claudin 10 | Not recorded | In 1 condition |
| FAM20AFAM20A golgi associated secretory pathway pseudokinase | Not recorded | In 1 condition |
| HNF1AHNF1 homeobox A | Not recorded | In 1 condition |
| IL6interleukin 6 | Not recorded | In 1 condition |
| KCNJ1potassium inwardly rectifying channel subfamily J member 1 | Not recorded | In 1 condition |
| KCNJ10potassium inwardly rectifying channel subfamily J member 10 | Not recorded | In 1 condition |
| MAGED2MAGE family member D2 | Not recorded | In 1 condition |
| NPHP4nephrocystin 4 | Not recorded | In 2 conditions |
| PLVAPplasmalemma vesicle associated protein | Not recorded | In 1 condition |
| SLC12A1solute carrier family 12 member 1 | Not recorded | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Not recorded | In 1 condition |
| SLC5A2solute carrier family 5 member 2 | Not recorded | In 1 condition |
| TMEM67transmembrane protein 67 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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