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Gene

ITSN1

intersectin 1

Summary

Cytogenetic location
21q22.11
Coordinates
Chromosome 21: 33,642,501–33,899,861 (GRCh38)
Exons
40 exons across 257.4 kb
Protein
1,721 amino acids
Also known as
SH3P17, MGC134948, MGC134949
Previous symbols
SH3D1A, ITSN
MANE Select transcript
ENST00000381318.8NM_003024.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephrotic Syndrome

    • Nephrosis

      Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

      • 1 GenCC submitter rates it definitive or strong

How ITSN1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 21, with a bracket where ITSN1 sits. ITSN1 and 16 genes near it on chromosome 21, from 33,271,181 to 34,271,180.Chromosome 2121q22.11p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.333.4 Mb33.6 Mb33.8 Mb34 Mb34.2 MbIFNAR2-IL10RB: 33,229,892–33,297,160, forward strandIFNAR2-IL10RBIL10RB: 33,265,958–33,311,420, forward strandIL10RBIFNAR1: 33,324,387–33,359,864, forward strandIFNAR1IFNGR2: 33,403,205–33,479,348, forward strandIFNGR2TMEM50B: 33,432,190–33,480,004, reverse strandTMEM50BDNAJC28: 33,485,615–33,491,753, reverse strandDNAJC28GART: 33,498,517–33,543,524, reverse strandGARTSON: 33,542,214–33,577,481, forward strandSONDONSON: 33,559,542–33,589,015, reverse strandDONSON: 33,584,687–33,931,607, reverse strandCRYZL1: 33,589,341–33,643,926, reverse strandCRYZL1ITSN1: 33,642,501–33,899,861, forward strandITSN1ATP5PO: 33,901,027–33,915,853, reverse strandATP5POMRPS6: 34,072,889–34,362,252, forward strandMRPS6SLC5A3: 34,073,509–34,106,260, forward strandSLC5A3: 34,073,509–34,143,037, forward strandKCNE2: 34,180,729–34,371,390, forward strandKCNE2Diagram of ITSN1: 40 exons on the forward strand of chromosome 21Exon 1: 33,642,501–33,642,713, 213 basesExon 2: 33,718,797–33,718,856, 60 basesExon 3: 33,721,178–33,721,270, 93 basesExon 4: 33,722,588–33,722,651, 64 basesExon 5: 33,735,044–33,735,204, 161 basesExon 6: 33,750,143–33,750,322, 180 basesExon 7: 33,751,810–33,751,906, 97 basesExon 8: 33,755,297–33,755,397, 101 basesExon 9: 33,761,923–33,761,986, 64 basesExon 10: 33,765,875–33,766,012, 138 basesExon 11: 33,767,713–33,767,828, 116 basesExon 12: 33,772,061–33,772,323, 263 basesExon 13: 33,774,729–33,774,878, 150 basesExon 14: 33,774,968–33,775,108, 141 basesExon 15: 33,781,461–33,781,548, 88 basesExon 16: 33,781,994–33,782,133, 140 basesExon 17: 33,794,341–33,794,468, 128 basesExon 18: 33,797,379–33,797,608, 230 basesExon 19: 33,799,808–33,799,929, 122 basesExon 20: 33,802,430–33,802,444, 15 basesExon 21: 33,810,975–33,811,222, 248 basesExon 22: 33,813,913–33,814,072, 160 basesExon 23: 33,818,267–33,818,472, 206 basesExon 24: 33,819,241–33,819,323, 83 basesExon 25: 33,823,487–33,823,653, 167 basesExon 26: 33,826,818–33,826,863, 46 basesExon 27: 33,829,624–33,829,745, 122 basesExon 28: 33,834,307–33,834,424, 118 basesExon 29: 33,836,441–33,836,632, 192 basesExon 30: 33,856,736–33,856,857, 122 basesExon 31: 33,858,686–33,858,792, 107 basesExon 32: 33,865,151–33,865,334, 184 basesExon 33: 33,867,233–33,867,331, 99 basesExon 34: 33,875,354–33,875,521, 168 basesExon 35: 33,882,243–33,882,455, 213 basesExon 36: 33,883,550–33,883,671, 122 basesExon 37: 33,885,041–33,885,123, 83 basesExon 38: 33,885,439–33,885,522, 84 basesExon 39: 33,886,287–33,886,460, 174 basesExon 40: 33,888,152–33,899,861, 11,710 bases15101520253035405′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 17 kb of the gene's 257.4 kb; 5,166 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ITSN1 gene: intersectin 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/itsn1

Vancouver

Dante Labs. ITSN1 gene: intersectin 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/itsn1

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