Trait
Reduced protein C activity
An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein C. Protein C is activated to protein Ca by thrombin bound to thrombomodulin. Activated protein C degrades factors VIIIa and Va.
Summary
- Also called
- Protein C deficiency
Reference genomeGRCh38hg38
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Read the genes linked to Reduced protein C activity, and the rest of your genome, with one test.
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Get my Genome Test10 genes linked to Reduced protein C activity
Changes in these genes cause rare conditions in which Reduced protein C activity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PROCprotein C, inactivator of coagulation factors Va and VIIIa | Always | In 2 conditions |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Often (30–79%) | In 1 condition |
| B4GALT1beta-1,4-galactosyltransferase 1 | Often (30–79%) | In 1 condition |
| DPM1dolichyl-phosphate mannosyltransferase subunit 1, catalytic | Often (30–79%) | In 2 conditions |
| GGCXgamma-glutamyl carboxylase | Often (30–79%) | In 2 conditions |
| MPImannose phosphate isomerase | Often (30–79%) | In 1 condition |
| VKORC1vitamin K epoxide reductase complex subunit 1 | Often (30–79%) | In 1 condition |
| ALG6ALG6 alpha-1,3-glucosyltransferase | Sometimes (5–29%) | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Sometimes (5–29%) | In 1 condition |
| NGLY1N-glycanase 1 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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