Trait
Hypofibrinogenemia
Decreased concentration of fibrinogen in the blood.
Summary
- Also called
- Low fibrinogen activity, Low fibrinogen level
Reference genomeGRCh38hg38
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Get my Genome Test45 genes linked to Hypofibrinogenemia
Changes in these genes cause rare conditions in which Hypofibrinogenemia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| MCM10minichromosome maintenance 10 replication initiation factor | Always | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| RC3H1ring finger and CCCH-type domains 1 | Always | In 1 condition |
| SLC19A1solute carrier family 19 member 1 | Always | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Always | In 1 condition |
| PRF1perforin 1 | Very often (80–99%) | In 2 conditions |
| STX11syntaxin 11 | Very often (80–99%) | In 2 conditions |
| XIAPX-linked inhibitor of apoptosis | Very often (80–99%) | In 1 condition |
| AHCYadenosylhomocysteinase | Often (30–79%) | In 1 condition |
| ANK1ankyrin 1 | Often (30–79%) | In 1 condition |
| CD46CD46 molecule | Often (30–79%) | In 1 condition |
| CFHcomplement factor H | Often (30–79%) | In 1 condition |
| CFIcomplement factor I | Often (30–79%) | In 1 condition |
| EPB42erythrocyte membrane protein band 4.2 | Often (30–79%) | In 1 condition |
| GNA14G protein subunit alpha 14 | Often (30–79%) | In 2 conditions |
| HELLPARHELLP associated long non-coding RNA | Often (30–79%) | In 1 condition |
| HMOX1heme oxygenase 1 | Often (30–79%) | In 1 condition |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Often (30–79%) | In 1 condition |
| SPTA1spectrin alpha, erythrocytic 1 | Often (30–79%) | In 1 condition |
| SPTBspectrin beta, erythrocytic | Often (30–79%) | In 1 condition |
| STXBP2syntaxin binding protein 2 | Often (30–79%) | In 1 condition |
| TNFRSF9TNF receptor superfamily member 9 | Often (30–79%) | In 1 condition |
| UNC13Dunc-13 homolog D | Often (30–79%) | In 2 conditions |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| FIP1L1factor interacting with PAPOLA and CPSF1 | Sometimes (5–29%) | In 1 condition |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Sometimes (5–29%) | In 1 condition |
| LYSTlysosomal trafficking regulator | Sometimes (5–29%) | In 1 condition |
| NABP1nucleic acid binding protein 1 | Sometimes (5–29%) | In 1 condition |
| NGLY1N-glycanase 1 | Sometimes (5–29%) | In 1 condition |
| NPM1nucleophosmin 1 | Sometimes (5–29%) | In 1 condition |
| NUMA1nuclear mitotic apparatus protein 1 | Sometimes (5–29%) | In 1 condition |
| PMLPML nuclear body scaffold | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| RARAretinoic acid receptor alpha | Sometimes (5–29%) | In 1 condition |
| SLC7A7solute carrier family 7 member 7 | Sometimes (5–29%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Sometimes (5–29%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Sometimes (5–29%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Sometimes (5–29%) | In 1 condition |
| ZBTB16zinc finger and BTB domain containing 16 | Sometimes (5–29%) | In 1 condition |
| B4GALT1beta-1,4-galactosyltransferase 1 | Not recorded | In 1 condition |
Show 5 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| FGAfibrinogen alpha chain | Not recorded | In 1 condition |
| FGBfibrinogen beta chain | Not recorded | In 1 condition |
| FGGfibrinogen gamma chain | Not recorded | In 1 condition |
| HAVCR2hepatitis A virus cellular receptor 2 | Not recorded | In 1 condition |
| NLRC4NLR family CARD domain containing 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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