Trait
Axonal loss
A reduction in the number of axons in the peripheral nervous system.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test21 genes linked to Axonal loss
Changes in these genes cause rare conditions in which Axonal loss is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| INF2inverted formin 2 | Always | In 1 condition |
| PMP22peripheral myelin protein 22 | Always | In 1 condition |
| RFC1replication factor C subunit 1 | Always | In 1 condition |
| SLC12A6solute carrier family 12 member 6 | Always | In 1 condition |
| GDAP1ganglioside induced differentiation associated protein 1 | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| GJB1gap junction protein beta 1 | Often (30–79%) | In 1 condition |
| NGLY1N-glycanase 1 | Sometimes (5–29%) | In 1 condition |
| ADPRSADP-ribosylserine hydrolase | Not recorded | In 1 condition |
| ASCC1activating signal cointegrator 1 complex subunit 1 | Not recorded | In 1 condition |
| BAG3BAG cochaperone 3 | Not recorded | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Not recorded | In 1 condition |
| MOCS1molybdenum cofactor synthesis 1 | Not recorded | In 1 condition |
| MOCS2molybdenum cofactor synthesis 2 | Not recorded | In 1 condition |
| NDRG1N-myc downstream regulated 1 | Not recorded | In 1 condition |
| SURF1SURF1 cytochrome c oxidase assembly factor | Not recorded | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Not recorded | In 1 condition |
| TRIP4thyroid hormone receptor interactor 4 | Not recorded | In 1 condition |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Not recorded | In 1 condition |
| UBQLN2ubiquilin 2 | Not recorded | In 1 condition |
| UBTFupstream binding transcription factor | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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