Trait
Involuntary writhing movements in fingers, hands, toes, and feet
Clinical name: Athetosis
A slow, continuous, involuntary writhing movement that prevents maintenance of a stable posture. Athetosis involves continuous smooth movements that appear random and are not composed of recognizable sub-movements or movement fragments. In contrast to chorea, in athetosis, the same regions of the body are repeatedly involved. Athetosis may worsen with attempts at movement of posture, but athetosis can also occur at rest.
Summary
- Also called
- Athetoid movements, Involuntary writhing movements
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Read the genes linked to Involuntary writhing movements in fingers, hands, toes, and feet, and the rest of your genome, with one test.
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Get my Genome Test69 genes linked to Involuntary writhing movements in fingers, hands, toes, and feet
Changes in these genes cause rare conditions in which Involuntary writhing movements in fingers, hands, toes, and feet is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCC8ATP binding cassette subfamily C member 8 | Always | In 1 condition |
| ACO2aconitase 2 | Always | In 1 condition |
| DDCdopa decarboxylase | Always | In 1 condition |
| DNM1Ldynamin 1L | Always | In 1 condition |
| FOXRED1FAD dependent oxidoreductase domain containing 1 | Always | In 1 condition |
| KIF5Akinesin family member 5A | Always | In 1 condition |
| SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor | Always | In 1 condition |
| TWNKtwinkle mtDNA helicase | Always | In 1 condition |
| UBA5ubiquitin like modifier activating enzyme 5 | Always | In 1 condition |
| UQCRQubiquinol-cytochrome c reductase complex III subunit VII | Always | In 1 condition |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Always | In 2 conditions |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Very often (80–99%) | In 1 condition |
| KCNJ10potassium inwardly rectifying channel subfamily J member 10 | Very often (80–99%) | In 1 condition |
| PRRT2proline rich transmembrane protein 2 | Very often (80–99%) | In 2 conditions |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Often (30–79%) | In 1 condition |
| CACNA1Dcalcium voltage-gated channel subunit alpha1 D | Often (30–79%) | In 2 conditions |
| GCDHglutaryl-CoA dehydrogenase | Often (30–79%) | In 1 condition |
| KCNQ2potassium voltage-gated channel subfamily Q member 2 | Often (30–79%) | In 1 condition |
| KCNQ3potassium voltage-gated channel subfamily Q member 3 | Often (30–79%) | In 1 condition |
| PLP1proteolipid protein 1 | Often (30–79%) | In 1 condition |
| POLR3KRNA polymerase III subunit K | Often (30–79%) | In 1 condition |
| RBM10RNA binding motif protein 10 | Often (30–79%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Often (30–79%) | In 1 condition |
| SCN8Asodium voltage-gated channel alpha subunit 8 | Often (30–79%) | In 1 condition |
| SLC6A8solute carrier family 6 member 8 | Often (30–79%) | In 1 condition |
| AQP4aquaporin 4 | Sometimes (5–29%) | In 1 condition |
| AUHAU RNA binding methylglutaconyl-CoA hydratase | Sometimes (5–29%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Sometimes (5–29%) | In 1 condition |
| CUX2cut like homeobox 2 | Sometimes (5–29%) | In 1 condition |
| CYB5Acytochrome b5 type A | Sometimes (5–29%) | In 1 condition |
| CYB5R3cytochrome b5 reductase 3 | Sometimes (5–29%) | In 1 condition |
| DPYSL5dihydropyrimidinase like 5 | Sometimes (5–29%) | In 1 condition |
| EPRS1glutamyl-prolyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| FTH1ferritin heavy chain 1 | Sometimes (5–29%) | In 1 condition |
| GAMTguanidinoacetate N-methyltransferase | Sometimes (5–29%) | In 1 condition |
| GNAO1G protein subunit alpha o1 | Sometimes (5–29%) | In 2 conditions |
| GPRC5BG protein-coupled receptor class C group 5 member B | Sometimes (5–29%) | In 1 condition |
| HCFC1host cell factor C1 | Sometimes (5–29%) | In 1 condition |
| HEPACAMhepatic and glial cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
Show 29 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MECRmitochondrial trans-2-enoyl-CoA reductase | Sometimes (5–29%) | In 1 condition |
| MLC1modulator of VRAC current 1 | Sometimes (5–29%) | In 1 condition |
| NGLY1N-glycanase 1 | Sometimes (5–29%) | In 2 conditions |
| PCpyruvate carboxylase | Sometimes (5–29%) | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Sometimes (5–29%) | In 1 condition |
| PHGDHphosphoglycerate dehydrogenase | Sometimes (5–29%) | In 1 condition |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Sometimes (5–29%) | In 1 condition |
| PYCR1pyrroline-5-carboxylate reductase 1 | Sometimes (5–29%) | In 1 condition |
| RNASET2ribonuclease T2 | Sometimes (5–29%) | In 1 condition |
| SPG21SPG21 abhydrolase domain containing, maspardin | Sometimes (5–29%) | In 1 condition |
| TRPM3transient receptor potential cation channel subfamily M member 3 | Sometimes (5–29%) | In 1 condition |
| YME1L1YME1 like 1 ATPase | Sometimes (5–29%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Rarely (1–4%) | In 2 conditions |
| FOXG1forkhead box G1 | Not recorded | In 1 condition |
| JAM2junctional adhesion molecule 2 | Not recorded | In 1 condition |
| MYORGmyogenesis regulating glycosidase | Not recorded | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Not recorded | In 1 condition |
| NDE1nudE neurodevelopment protein 1 | Not recorded | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Not recorded | In 1 condition |
| PIGVphosphatidylinositol glycan anchor biosynthesis class V | Not recorded | In 1 condition |
| SLC16A2solute carrier family 16 member 2 | Not recorded | In 1 condition |
| SLC17A5solute carrier family 17 member 5 | Not recorded | In 1 condition |
| SLC20A2solute carrier family 20 member 2 | Not recorded | In 1 condition |
| SLC46A1solute carrier family 46 member 1 | Not recorded | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Not recorded | In 1 condition |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Not recorded | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Not recorded | In 1 condition |
| UBQLN2ubiquilin 2 | Not recorded | In 1 condition |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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