Trait
Decreased facial muscle tone
Clinical name: Facial hypotonia
Reduced muscle tone of a muscle that is innervated by the facial nerve (the seventh cranial nerve).
Summary
- Also called
- Low facial muscle tone, Reduced facial muscle tone, Hypotonic facies
Reference genomeGRCh38hg38
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Get my Genome Test57 genes linked to Decreased facial muscle tone
Changes in these genes cause rare conditions in which Decreased facial muscle tone is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DYNC1H1dynein cytoplasmic 1 heavy chain 1 | Always | In 1 condition |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Always | In 1 condition |
| GPC3glypican 3 | Always | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Always | In 2 conditions |
| NGLY1N-glycanase 1 | Always | In 2 conditions |
| SATB2SATB homeobox 2 | Always | In 1 condition |
| SLC30A9solute carrier family 30 member 9 | Always | In 1 condition |
| UNC80unc-80 subunit of NALCN channel complex | Always | In 1 condition |
| CHAMP1chromosome alignment maintaining phosphoprotein 1 | Very often (80–99%) | In 1 condition |
| DMPKDM1 protein kinase | Very often (80–99%) | In 1 condition |
| AP4B1adaptor related protein complex 4 subunit beta 1 | Often (30–79%) | In 1 condition |
| AP4E1adaptor related protein complex 4 subunit epsilon 1 | Often (30–79%) | In 2 conditions |
| AP4M1adaptor related protein complex 4 subunit mu 1 | Often (30–79%) | In 1 condition |
| AP4S1adaptor related protein complex 4 subunit sigma 1 | Often (30–79%) | In 2 conditions |
| ASXL1ASXL transcriptional regulator 1 | Often (30–79%) | In 1 condition |
| FBXO22F-box protein 22 | Often (30–79%) | In 1 condition |
| GAAalpha glucosidase | Often (30–79%) | In 1 condition |
| KCNK4potassium two pore domain channel subfamily K member 4 | Often (30–79%) | In 1 condition |
| KDM4Blysine demethylase 4B | Often (30–79%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Often (30–79%) | In 2 conditions |
| PPP2R1Aprotein phosphatase 2 scaffold subunit Aalpha | Often (30–79%) | In 2 conditions |
| RNU4-2RNA, U4 small nuclear 2 | Often (30–79%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 1 condition |
| TET3tet methylcytosine dioxygenase 3 | Often (30–79%) | In 1 condition |
| XYLT2xylosyltransferase 2 | Often (30–79%) | In 1 condition |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Sometimes (5–29%) | In 1 condition |
| BORCS8BLOC-1 related complex subunit 8 | Sometimes (5–29%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Sometimes (5–29%) | In 1 condition |
| GRIA3glutamate ionotropic receptor AMPA type subunit 3 | Sometimes (5–29%) | In 1 condition |
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Sometimes (5–29%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 1 condition |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Sometimes (5–29%) | In 1 condition |
| MYOTmyotilin | Sometimes (5–29%) | In 1 condition |
| PAX7paired box 7 | Sometimes (5–29%) | In 1 condition |
| POU3F3POU class 3 homeobox 3 | Sometimes (5–29%) | In 1 condition |
| PURApurine rich element binding protein A | Sometimes (5–29%) | In 1 condition |
| RAB11BRAB11B, member RAS oncogene family | Sometimes (5–29%) | In 1 condition |
| RHOBTB2Rho related BTB domain containing 2 | Sometimes (5–29%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Sometimes (5–29%) | In 1 condition |
Show 17 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SETSET nuclear proto-oncogene | Sometimes (5–29%) | In 1 condition |
| SLC1A3solute carrier family 1 member 3 | Sometimes (5–29%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Sometimes (5–29%) | In 1 condition |
| SRRM2serine/arginine repetitive matrix 2 | Sometimes (5–29%) | In 1 condition |
| STRADASTE20 related adaptor alpha | Sometimes (5–29%) | In 2 conditions |
| YY1YY1 transcription factor | Sometimes (5–29%) | In 2 conditions |
| ZSCAN10zinc finger and SCAN domain containing 10 | Sometimes (5–29%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Rarely (1–4%) | In 1 condition |
| AMPD2adenosine monophosphate deaminase 2 | Not recorded | In 1 condition |
| CAMK2Gcalcium/calmodulin dependent protein kinase II gamma | Not recorded | In 1 condition |
| DSEdermatan sulfate epimerase | Not recorded | In 1 condition |
| KDM5Clysine demethylase 5C | Not recorded | In 1 condition |
| PCGF2polycomb group ring finger 2 | Not recorded | In 1 condition |
| PPP2R5Dprotein phosphatase 2 regulatory subunit B'delta | Not recorded | In 1 condition |
| VPS13Bvacuolar protein sorting 13 homolog B | Not recorded | In 1 condition |
| ZBTB11zinc finger and BTB domain containing 11 | Not recorded | In 1 condition |
| ZMIZ1zinc finger MIZ-type containing 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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