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Gene

SIRT1

sirtuin 1

Summary

Cytogenetic location
10q21.3
Coordinates
Chromosome 10: 67,884,656–67,918,390 (GRCh38)
Exons
9 exons across 33.7 kb
Protein
747 amino acids
Also known as
SIR2L1
MANE Select transcript
ENST00000212015.11NM_012238.5
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SIRT1 yet. The test sequences your whole genome, so your data includes it all the same.

How SIRT1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 10, with a bracket where SIRT1 sits. SIRT1 and 8 genes near it on chromosome 10, from 67,401,523 to 68,401,522.Chromosome 1010q21.3p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.367.6 Mb67.8 Mb68 Mb68.2 Mb68.4 MbCTNNA3: 65,912,457–67,763,637, reverse strandCTNNA3DNAJC12: 67,796,665–67,850,195, reverse strandDNAJC12SIRT1: 67,884,656–67,918,390, forward strandSIRT1HERC4: 67,921,899–68,075,353, reverse strandHERC4MYPN: 68,087,897–68,212,017, forward strandMYPNATOH7: 68,230,595–68,232,113, reverse strandATOH7PBLD: 68,262,014–68,334,114, reverse strandPBLDHNRNPH3: 68,331,174–68,344,002, forward strandHNRNPH3RUFY2: 68,341,107–68,407,381, reverse strandRUFY2Diagram of SIRT1: 9 exons on the forward strand of chromosome 10Exon 1: 67,884,656–67,885,151, 496 basesExon 2: 67,887,417–67,887,533, 117 basesExon 3: 67,888,882–67,889,123, 242 basesExon 4: 67,891,402–67,891,554, 153 basesExon 5: 67,906,790–67,906,937, 148 basesExon 6: 67,908,046–67,908,125, 80 basesExon 7: 67,909,256–67,909,442, 187 basesExon 8: 67,912,474–67,913,031, 558 basesExon 9: 67,916,265–67,918,390, 2,126 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 33.7 kb; 2,244 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). SIRT1 gene: sirtuin 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/sirt1

Vancouver

Dante Labs. SIRT1 gene: sirtuin 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/sirt1

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